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CDH1

cadherin 1, type 1, E-cadherin (epithelial)

Synonyms:
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Species:
UniProtKB ID:
Gene ID:
  • Human(999) Summary: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
  • Mouse(12550) cadherin 1
  • Rat(83502) cadherin 1
  • dog(442858) cadherin 1, type 1, E-cadherin (epithelial)
  • chicken(415860) cadherin 1, type 1, E-cadherin (epithelial)
  • sheep(100294601) cadherin 1, type 1, E-cadherin (epithelial)
  • domestic guinea pig(100726210) cadherin 1, type 1, E-cadherin (epithelial)
  • domestic cat(101095391) cadherin 1, type 1, E-cadherin (epithelial)
  • sheep(101119747) cadherin 1, type 1, E-cadherin (epithelial)
  • naked mole-rat(101719565) cadherin 1, type 1, E-cadherin (epithelial)
  • Zebrafish(114424) cadherin 1, epithelial
  • cow(282637) cadherin 1, type 1, E-cadherin (epithelial)

Custom & Knockdown Gene Products

ELISA

Product Number
Description
Species
Mouse E-Cadherin ELISA Kit, for serum, plasma and cell culture supernatant,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-E-Cadherin Antibody, clone 1G14 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
flow cytometry

immunofluorescence

immunohistochemistry

western blot
Anti-E-Cadherin antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-E-Cadherin antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Phospho-CDH1-S838/S840 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Anti-E-Cadherin Antibody, clone 67A4, Azide & Ascites Free, clone 67A4, 0.5 mg/mL, from mouse,
Species Reactivity
human
Application
flow cytometry
immunofluorescence

inhibition assay

western blot

Cell Lines

Product Number
Description
Species
MCF10A CELLS CDH1 (-/-), ,
Species
human

Proteins

Product Number
Description
Species
E-Cadherin/Fc Chimera from mouse, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
Species
mouse
E-Cadherin human, recombinant, expressed in E. coli, 0.5 mg protein/mL,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CDH1,
Species
human
MISSION® esiRNA, targeting mouse Cdh1,
Species
mouse