FLT3
fms-related tyrosine kinase 3
Synonyms:
CD135, FLK-2, FLK2, STK1
Species:
Human FLT3 (2322), Mouse Flt3 (14255), Rat Flt3 (140635), Horse FLT3 (100061780), dog FLT3 (486025), chicken FLT3 (100858422), domestic cat FLT3 (101099264), Domestic Rabbit FLT3 (100342842), Zebrafish flt3 (566708), sheep FLT3 (101112331) ...More
UniProtKB ID:
Gene ID:
- Human(2322) Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
- Mouse(14255) FMS-like tyrosine kinase 3
- Rat(140635) fms-related tyrosine kinase 3
- Horse(100061780) fms-related tyrosine kinase 3
- dog(486025) fms-related tyrosine kinase 3
- chicken(100858422) fms-related tyrosine kinase 3
- domestic cat(101099264) fms-related tyrosine kinase 3
- Domestic Rabbit(100342842) fms-related tyrosine kinase 3
- Zebrafish(566708) fms-related tyrosine kinase 3
- sheep(101112331) fms-related tyrosine kinase 3
- naked mole-rat(101713724) fms-related tyrosine kinase 3
- cow(512700) fms-related tyrosine kinase 3
- domestic guinea pig(100732047) fms-related tyrosine kinase 3
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Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
Flt-3 (D835Y) Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant human Flt3 amino acids 564-end, containing the mutation D835Y, for use in Kinase Assays.,
Species
human
Flt-3 Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant human Flt3, amino acids 564 -end. For use in Kinase Assays.,
Species
human