HomeIntegrated OfferingsBiopharma 4.0: Digital Transformation to an Intensified, Closed, Connected, or Continuous BioprocessClosed Processing for Biomanufacturing

Closed Processing for Biomanufacturing

Closed Processing

The facility of the future will require transformation in how biologics are developed and manufactured. Closed processing mitigates contamination and safety risks, maximizes new and existing facility and asset utilization, while enabling sustainable multi-modal manufacturing. With closed processing costly cleanroom and environmental control measures are reduced without compromising product quality. Simplified space design, smaller cleanroom footprints, and increased operational flexibility allow for dramatic cost savings and future-readiness, today.

Close your process. Open your possibilities.

With closed processing, you can:

Mitigate contamination and safety risks
Reduce costly and environmentally demanding cleanroom control measures without compromising product quality
Enable connected and continuous process manufacturing
Maximize operational flexibility
Enable sustainable multi-modal manufacturing

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Value drivers & benefits of closed bioprocessing

47% reduction in contamination risk

81% reduction in gowning costs

47% reduction in labor time due to reduced gowning, room cleaning, and equipment sanitization

Up to 53% reduction in environmental monitoring

Up to 65% reduction in energy consumption

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Related Podcast

Putting Biologics on the Fast Lane Podcast

Tune in & enter the world of Bioprocessing 4.0 with Merrilee Whitney, Chris Hwang and Kelvin Lee. In this podcast we discuss how to accelerate the production of biologics to a rapid pace.

Related Webinars

Webinar on the benefits of single use closed processing for biopharmaceutical manufacturing

Closed Concept for Biopharmaceutical Manufacturing Webinar

Uncover the benefits and challenges associated with closed processing and learn how innovations in closed single-use systems are driving greater manufacturing efficiency.

Single-Use Tangential Flow Filtration for Closed Processing Webinar

In this webinar, we present the design and performance testing of a single-use manufacturing-scale TFF system that can be operated in functionally or fully closed mode.

Webinar on regulatory expectations when implementing closed single use systems for final filtration and filling operations.

Single-Use Systems - A Prerequisite for Closed Processing in Final Filtration and Filling Operation Webinar

Learn about regulatory expectations when implementing single-use systems for final filtration and filling applications.

Webinar on updates to EU GMP Annex 1 and how this impacts sterilizing filtration in single use systems

How Updates to EU GMP Annex 1 Impact Sterilizing Filtration in Single-Use Systems Webinar

In this webinar, we discuss important elements of the revision to EU GMP Annex 1 and how single-use filtration systems can contribute to a holistic contamination control strategy.

Related Product Categories

Connection/Disconnection for Bioprocessing

Our single-use or stainless steel-based fluid transfer systems feature Lynx sterile connectors and various tubing types to provide sterile fluid transfer between steps in your aseptic bioprocess.

Chromatography Systems for Bioprocessing

Single-use and multi-use chromatography systems are critical for the separation of your valuable molecules. We provide standard and custom systems from pilot to process-scale, offering robust and consistent performance with the processing flexibility you need.

Final Sterile Filtration & Filling

Pre-sterilized, single-use filling systems offer speed and flexibility for critical final filtration and final fill operations. Learn how advances in aseptic filtration simplify PUPSIT and enable optimized sterile fill finish operations.

Sterile Sampling

Flexible. Safe. Contamination free. Closed system ensures aseptic processing conditions. With configurable holders and single-use sampling assemblies, NovaSeptum^® GO sterile sampling system provides representative samples for QC labs testing for bioburden, endotoxin, process sterility, and monitoring pH and osmolality.

Single-Use Assemblies

Mobius^® 2D and 3D single-use assemblies and systems for sterile fluid management offer flexible manufacturing options for biopharmaceutical companies, from frozen transport and storage, media and buffer preparation to final fill applications.

Sterile Filters

Sterile filtration with disposable filters is a common operation in bioprocessing and part of every bioburden control strategy. Sterile filtration assures microbial safety of the drug for patients. Learn how to select the best sterilizing filter for your process step.

Prefilters & Bioburden Control

Prefilters are used to remove particulates and protect downstream unit operations. They can be used to provide column protection or in front of a sterilizing-grade filter to improve capacity. Learn how our cost-effective prefilters can enhance your process economics.

Tangential Flow Filtration Holders & Systems

Our tangential flow (crossflow) filtration systems are engineered for low hold-up volume, maximum volume concentration, and optimal product recovery in single-use and multi-use applications from process development to large-scale manufacturing, with compatible holders available for expendables.