Merck
All Photos(3)

1.01544

SAFC

L-Arginine monohydrochloride

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

Synonym(s):
(S)-(+)-Arginine hydrochloride, α-Amino-δ-guanidino valerianic acid hydrochloride, alpha-Amino-delta-guanidino valerianic acid hydrochloride, Arg, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride
Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
CAS Number:
Molecular Weight:
210.66
Beilstein:
3631658
MDL number:
EC Index Number:
214-275-1

Quality Level

Agency

BP
ChP
JP
Ph. Eur.
USP

vapor pressure

<1 Pa ( 20 °C)

product line

EMPROVE® EXPERT

assay

98.5-101.0% dry basis (perchloric acid titration)

form

solid

pH

5.7 (20 °C, 100 g/L in H2O)

mp

>235 °C

solubility

water: 730 g/L at 20 °C

density

1.42 g/cm3 at 20 °C

anion traces

chloride (Cl-): 16.5-17.1%
sulfate (SO42-): ≤200 ppm

cation traces

As: ≤2 ppm
Fe: ≤10 ppm
NH4+: ≤200 ppm
heavy metals (as Pb): ≤10 ppm

application(s)

biopharma process and formulation
liquid formulation
parenterals
pharmaceutical

storage temp.

2-30°C

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

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General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Arginine hydrochloride has several applications in biopharma manufacturing such as an additive for protein refolding, aggregate suppression, viscosity reduction, and buffer for chromatography.
Due to its low microbial and endotoxin limits, L-Arginine monohydrochloride Emprove® Expert is suitable for high-risk applications.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Quality

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What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

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Why are these documents unavailable?
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