1.01544

L-Arginine monohydrochloride

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Synonym(s): (S)-(+)-Arginine hydrochloride, α-Amino-δ-guanidino valerianic acid hydrochloride, alpha-Amino-delta-guanidino valerianic acid hydrochloride, Arg, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride
• Empirical Formula (Hill Notation): C₆H₁₄N₄O₂ · HCl
• CAS Number: 1119-34-2
• Molecular Weight: 210.66
• Beilstein: 3631658
• MDL number: MFCD00064550
• EC Index Number: 214-275-1

Properties

• Quality Level: 500
• Agency: BP; ChP; JP; Ph. Eur.; USP
• vapor pressure: <1 Pa ( 20 °C)
• product line: EMPROVE^® EXPERT
• assay: 98.5-101.0% dry basis (perchloric acid titration)
• form: solid
• pH: 5.7 (20 °C, 100 g/L in H₂O)
• mp: >235 °C
• solubility: water: 730 g/L at 20 °C
• density: 1.42 g/cm³ at 20 °C
• anion traces: chloride (Cl^-): 16.5-17.1%; sulfate (SO₄^2-): ≤200 ppm
• cation traces: As: ≤2 ppm; Fe: ≤10 ppm; NH₄⁺: ≤200 ppm; heavy metals (as Pb): ≤10 ppm
• application(s): biopharma process and formulation; liquid formulation; parenterals; pharmaceutical
• storage temp.: 2-30°C
• SMILES string: Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
• InChI key: KWTQSFXGGICVPE-WCCKRBBISA-N

Description

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Arginine hydrochloride has several applications in biopharma manufacturing such as an additive for protein refolding, aggregate suppression, viscosity reduction, and buffer for chromatography.
Due to its low microbial and endotoxin limits, L-Arginine monohydrochloride Emprove^® Expert is suitable for high-risk applications.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable