Merck

1.37096

SAFC

D-Mannitol

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

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Synonym(s):
Mannite
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein:
1721898
MDL number:
EC Index Number:
200-711-8

Agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

product line

EMPROVE® EXPERT

form

solid

autoignition temp.

410 °C

pH

5-7 (20 °C, 100 g/L in H2O)

bp

290-295 °C/4 hPa

mp

167-170 °C (lit.)

solubility

213 g/L

application(s)

liquid formulation
ophthalmics
parenterals
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-25°C

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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1 of 4

This Item
1.05988M9546M1902
D-Mannitol EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

SAFC

1.37096

D-Mannitol

-
D-Mannitol fine powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 421

SAFC

1.05988

D-Mannitol

-
D-Mannitol BioXtra, ≥98% (HPLC)

Sigma-Aldrich

M9546

D-Mannitol

Premium Grade
D-Mannitol suitable for plant cell culture

Sigma-Aldrich

M1902

D-Mannitol

-
form

solid

form

fine powder

form

powder

form

powder

mp

167-170 °C (lit.)

mp

167-170 °C (lit.)

mp

167-170 °C (lit.)

mp

167-170 °C (lit.)

solubility

213 g/L

solubility

-

solubility

H2O: 1 M, clear, colorless

solubility

water: soluble 182 g/L at 20 °C (68 °F)

storage temp.

2-25°C

storage temp.

2-25°C

storage temp.

-

storage temp.

-

Quality Level

500

Quality Level

500

Quality Level

200

Quality Level

200

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Mannitol is a sugar alcohol which is used widely in biomolecule formulations as a stabilizer, bulking agent, and lyoprotecting agent, especially in lyophilization.
Due to its low microbial and endotoxin limits, D(-)-Mannitol Emprove® Expert is especially suitable for high-risk applications.

Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1


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SAFC

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Sigma-Aldrich

M9647

D-Mannitol

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Sigma-Aldrich

63559

D-Mannitol

D-Mannitol ≥99.9999% (metals basis), for boron determination

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Mannitol European Pharmacopoeia (EP) Reference Standard

M0200000

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Sigma-Aldrich

Sigma-Aldrich

8.18856

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Mannitol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1007

Mannitol

Mannitol British Pharmacopoeia (BP) Reference Standard

BP1007

Mannitol

Mannitol United States Pharmacopeia (USP) Reference Standard

USP

1375105

Mannitol

Articles

This overview describes the challenges when developing parenteral formulations and strategies to overcome them and reduce the risk of production.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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