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Unsaturated free fatty acids: a potential biomarker panel for early detection of gastric cancer.

Unsaturated free fatty acids: a potential biomarker panel for early detection of gastric cancer.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2014-10-31)

Yaping Zhang, Ling Qiu, Yanmin Wang, Chengyan He, Xuzhen Qin, Yujie Liu, Zhili Li

ABSTRACT

Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C16:1, C18:3, C18:2, C18:1, C20:4, and C22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly decreased compared with 252 healthy controls. Receiver operating characteristic analysis showed that the biomarker panel including C16:1, C18:3, C18:2, C20:4, and C22:6 presents a high diagnostic ability to differentiate early-stage GC patients from healthy controls plus BGD patients, with a sensitivity of 80.6% and a specificity of 72.7%.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Ethanol, absolute, sales not in Germany, ≥99.8% (vol.)

Sigma-Aldrich

Methanol solution, suitable for NMR (reference standard), 4% in methanol-d₄ (99.8 atom % D), NMR tube size 3 mm × 8 in.

Supelco

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Supelco

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Acetonitrile, suitable for HPLC-GC, ≥99.8% (GC)

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Acetonitrile, ≥99.9% (GC)

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Acetonitrile, HPLC Plus, ≥99.9%

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Acetonitrile, suitable for HPLC, gradient grade, ≥99.9%

USP

Residual Solvent Class 2 - Acetonitrile, United States Pharmacopeia (USP) Reference Standard

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Acetonitrile, ReagentPlus^®, 99%

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Ultrapure Acetonitrile

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Acetonitrile, ACS reagent, ≥99.5%

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Acetonitrile, suitable for DNA synthesis, ≥99.9% (GC)

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Ethyl alcohol, Pure, 200 proof, ACS reagent, ≥99.5%

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, meets USP testing specifications

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Acetonitrile, ≥99.8% (GC)

USP

Methyl alcohol, United States Pharmacopeia (USP) Reference Standard

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Ammonium acetate, 99.999% trace metals basis

Supelco

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Ammonium acetate, BioUltra, ≥99.0%

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Ammonium acetate solution, BioUltra, ~5 M in H₂O