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Ultrafiltration/Diafiltration (UF/DF) in Plasmid DNA Manufacturing

How are ultrafiltration and diafiltration used in plasmid DNA manufacturing and how should you optimize this process? Learn more in our technical article and download our free eBook.

Water Determination in Liquefied Petroleum Gas using GC BID and Ionic Liquid Column Watercol™

Using Watercol™ GC columns in conjunction with GC-BID can provide a reliable and practical option for Water determination in petrochemical feedstocks.

Viral Safety in Bioprocessing

Viral safety in bioprocessing relies on a framework of (1) preventing contamination, (2) detecting contamination, and (3) removing or inactivating viral contaminants.

Tangential Flow Filtration in the Antibody Drug Conjugate (ADC) Manufacturing Process

Find best practices for using Pellicon® Capsules in ADC processing as well as data from two studies using Pellicon® Capsules and Pellicon® cassettes in the ADC manufacturing process.

Scalable Tangential Flow Filtration (TFF) for Downstream Processing of Viral Vectors for Gene Therapy and Vaccine Production

Our overview of scalable tangential flow filtration for viral vector production will provide key considerations for developing and optimizing your downstream process.

Bioburden Control in Bioprocessing

Bioburden control in bioprocessing requires assessing the risks, mitigating the risks, and monitoring bioburden levels.

Viscosity Reduction in High Concentration TFF

This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.

Membrane Prefilters Improve Sterilizing Filter Capacity and Process Economics in Bioprocessing

Prefilters can be used throughout bioprocessing to remove to remove particulates, improve quality and protect sterilizing filters and downstream unit operations.

Renewable Electricity Toolkit

The Renewable Electricity Supplier Toolkit helps suppliers learn renewable electricity basics and how to bring projects to life.

Solubility and Dissolution Enhancement Via Formulation

Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.

Cell Counting Using a Hemocytometer

Cell counting protocol using a hemocytometer for monitoring cell viability. Discover other cell counting tools such as the Scepter™ 3.0 Cell Counter.

Quantification and Quality Control via CCM Fingerprinting

Learn about rapid and cost-effective identification of more than 100 media formulation components using LC-MS cell culture media fingerprinting.

Sterilizing Grade Filtration Unit Operations for Plasmid DNA Processes

We discuss the final filtration step of plasmid DNA manufacturing and its key considerations and challenges. Download our free pDNA downstream purification eBook or ask our experts.

An Introduction to Horseradish Peroxidase (HRP) and Its Applications

Horseradish peroxidase (HRP) is an enzyme used for detecting molecules, degrading toxins, cross-linking proteins, and in diagnostics like lateral flow assays.

Single-Pass Tangential Flow Filtration Implementation and Scaling

Get practical guidance on using single-pass tangential flow filtration in your downstream process and scaling between capsules and cassettes.

Tangential Flow Filtration in Downstream Bioprocessing

There are many options for tangential flow filtration (TFF) in downstream bioprocessing from multi-use to single-use TFF or batch TFF and single-pass TFF.

Purification of Extracellular Vesicles with Eshmuno^® Q Resin and Natrix^® Q Membrane

Separation and purification of subpopulations of extracellular vesicles (EVs) using Eshmuno® Q anion exchange resin and Natrix® Q membrane chromatography.

Allergenic Fragrance Testing – Certified Materials

IFRA method introduces new CRMs for allergenic fragrances, analyzed by GC with ionic liquid capillary column for selectivity.

FAME Standard for Optimizing GC System Performance

AOCS and AOAC methods for determining the trans fatty acid composition of foods by gas chromatography require the use of a highly polar cyanosilicone capillary column to provide the best peak resolution attainable of the numerous geometric (cis & trans)

Fast and Reliable Environmental Analysis of Aldehyde and Ketone Air Pollutants

Aldehydes and ketones are ubiquitous air pollutants. Along with esters and ethers, they are major components of indoor air pollution and are therefore important for industrial hygiene applications.

Hydrocarbon Oil Index in Samples

Special mineral oil standard mixtures are gravimetrically produced for calibration.

Neonicotinoids

Learn more about Neonicotinoids - active substances used in plant protection products to control harmful insects.

New GC-MS Method for Mycotoxin Analysis

An article regarding A New GC-MS Method for Mycotoxin Analysis Using 13C-marked Mycotoxin Derivatives from Sigma-Aldrich.com

HPLC Analysis of Superoxide Dismutase on Discovery® BIO PolyMA-WAX

Separation of Superoxide dismutase

HPLC Analysis of the Monoclonal Antibody (mAb) Erbitux (Cetuximab) on BIOshell A400 Protein C4

HPLC Analysis of the Monoclonal Antibody (mAb) Erbitux (Cetuximab) on BIOshell™ A400 Protein C4

Simple Urine Drug Screening with MS β-glucuronidase: Quick Start Guide and Demo Video

MS β-glucuronidase urinalysis workflow overview, features and benefits, and quick start guide video for your drug testing application needs.

Analytical Method: Aluminium (total) in effluents

Photometric determination with Chromazurole S subsequent to acid mineralisation; DIN decomposition

Analytical Method: Analytical Quality Assurance, Standard for Free Chlorine (DIN)

Preparation of a standard solution for free Chlorine according to DIN EN ISO 7393

Analytical Method: Analytical Quality Assurance, Standard for Hydrogen peroxide

Preparation of a standard solution for Hydrogen peroxide

Analytical Method: Analytical Quality Assurance, Standard for Sulfide

Preparation of a standard solution for Sulfide

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