ANK2
ankyrin 2, neuronal
Sinónimos:
ANK-2, LQT4, brank-2
Especie:
Human ANK2 (287), Mouse Ank2 (109676), Rat Ank2 (362036), naked mole-rat Ank2 (101697466), domestic guinea pig Ank2 (100717265), sheep ANK2 (101115623), chicken ANK2 (422689), domestic cat ANK2 (101100129), dog ANK2 (487908), fruit fly Ank2 (38863)
ID UniProtKB:
ID del gen:
- Human(287) Summary: This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
- Mouse(109676) ankyrin 2, brain
- Rat(362036) ankyrin 2, neuronal
- naked mole-rat(101697466) ankyrin 2, neuronal
- domestic guinea pig(100717265) ankyrin 2, neuronal
- sheep(101115623) ankyrin 2, neuronal
- chicken(422689) ankyrin 2, neuronal
- domestic cat(101100129) ankyrin 2, neuronal
- dog(487908) ankyrin 2, neuronal
- fruit fly(38863) Ankyrin 2
- Horse(100064198) ankyrin 2, neuronal
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