DUT
deoxyuridine triphosphatase
Sinónimos:
dUTPase
Especie:
Human DUT (1854), Mouse Dut (110074), Rat Dut (497778), Zebrafish dut (449835), chicken DUT (769338), domestic cat DUT (101099971), dog DUT (609526), cow DUT (507945), sheep DUT (101110765), naked mole-rat Dut (101718828)
ID UniProtKB:
ID del gen:
- Human(1854) Summary: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
- Mouse(110074) deoxyuridine triphosphatase
- Rat(497778) deoxyuridine triphosphatase
- Zebrafish(449835) dUTP pyrophosphatase
- chicken(769338) deoxyuridine triphosphatase
- domestic cat(101099971) deoxyuridine triphosphatase
- dog(609526) deoxyuridine triphosphatase
- cow(507945) deoxyuridine triphosphatase
- sheep(101110765) deoxyuridine triphosphatase
- naked mole-rat(101718828) deoxyuridine triphosphatase
- domestic guinea pig(100717103) deoxyuridine triphosphatase
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Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
KD-Validated Anti DUT Antibody, clone 23GB5240, Rabbit Monoclonal, clone 23GB5240, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reactividad de especies
human
Aplicación
flow cytometry
western blot
western blot