EDARADD
EDAR-associated death domain
Sinónimos:
ECTD11A, ECTD11B, ED3, EDA3
Especie:
Human EDARADD (128178), Mouse Edaradd (171211), Rat Edaradd (498769), domestic guinea pig Edaradd (100169691), naked mole-rat Edaradd (101704944), cow EDARADD (518089), chicken EDARADD (497625), Zebrafish edaradd (566761), dog EDARADD (607372), domestic cat EDARADD (101085497)
ID UniProtKB:
ID del gen:
- Human(128178) Summary: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Mouse(171211) EDAR (ectodysplasin-A receptor)-associated death domain
- Rat(498769) EDAR-associated death domain
- domestic guinea pig(100169691) EDAR (ectodysplasin-A receptor)-associated death domain
- naked mole-rat(101704944) EDAR-associated death domain
- cow(518089) EDAR-associated death domain
- chicken(497625) EDAR-associated death domain
- Zebrafish(566761) EDAR-associated death domain
- dog(607372) EDAR-associated death domain
- domestic cat(101085497) EDAR-associated death domain
- sheep(101115598) EDAR-associated death domain
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