F11
coagulation factor XI
Sinónimos:
FXI
Especie:
Human F11 (2160), Mouse F11 (109821), Rat F11 (290757), chicken F11 (422723), naked mole-rat F11 (101717554), domestic guinea pig F11 (100715511), Domestic Rabbit F11 (100009596), sheep F11 (101116630), cow F11 (407998), Horse F11 (100056603) ...Más
ID UniProtKB:
ID del gen:
- Human(2160) Summary: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
- Mouse(109821) coagulation factor XI
- Rat(290757) coagulation factor XI
- chicken(422723) coagulation factor XI
- naked mole-rat(101717554) coagulation factor XI
- domestic guinea pig(100715511) coagulation factor XI
- Domestic Rabbit(100009596) coagulation factor XI
- sheep(101116630) coagulation factor XI
- cow(407998) coagulation factor XI
- Horse(100056603) coagulation factor XI
- domestic cat(101094340) coagulation factor XI
- domestic cat(493756) coagulation factor XI
- dog(475623) coagulation factor XI
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