FAS
Fas cell surface death receptor
Sinónimos:
ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Especie:
Human FAS (355), Mouse Fas (14102), Rat Fas (246097), fruit fly fas (36521), Zebrafish fas (768248), chicken FAS (395274), dog FAS (486469), domestic cat FAS (493881), Horse FAS (100071639), cow FAS (282488) ...Más
ID UniProtKB:
ID del gen:
- Human(355) Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
- Mouse(14102) Fas (TNF receptor superfamily member 6)
- Rat(246097) Fas cell surface death receptor
- fruit fly(36521) faint sausage
- Zebrafish(768248) Fas (TNF receptor superfamily, member 6)
- chicken(395274) Fas (TNF receptor superfamily, member 6)
- dog(486469) Fas (TNF receptor superfamily, member 6)
- domestic cat(493881) Fas (TNF receptor superfamily, member 6)
- Horse(100071639) Fas (TNF receptor superfamily, member 6)
- cow(282488) Fas (TNF receptor superfamily, member 6)
- sheep(100144426) Fas (TNF receptor superfamily, member 6)
- Domestic Rabbit(100008609) Fas (TNF receptor superfamily, member 6)
- domestic guinea pig(100726403) Fas cell surface death receptor
- naked mole-rat(101704746) Fas cell surface death receptor
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Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-Fas (humano, activador), clon CH11, clone CH11, Upstate®, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
immunocytochemistry
western blot
immunocytochemistry
western blot
Anticuerpo anti-Fas (humano, neutralizante), clon ZB4, clone ZB4, Upstate®, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
neutralization
western blot
neutralization
western blot
Anti-Fas Antibody, clone SM1/1, clone SM1/1, Chemicon®, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
Anti-Fas/CD95 Antibody, clone 1F17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey
Aplicación
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-Fas Antibody, clone 7C10, clone 7C10, Upstate®, from rat,
Reactividad de especies
bovine, mouse
Aplicación
immunoprecipitation (IP)
western blot
western blot