PCBP2
poly(rC) binding protein 2
Sinónimos:
HNRNPE2, HNRPE2, hnRNP-E2
Especie:
Human PCBP2 (5094), Mouse Pcbp2 (18521), Rat Pcbp2 (363005), naked mole-rat Pcbp2 (101702918), Zebrafish pcbp2 (321844), dog PCBP2 (477596), domestic cat PCBP2 (101086733), Horse PCBP2 (100062163), cow PCBP2 (540653), sheep PCBP2 (101103142)
ID UniProtKB:
ID del gen:
- Human(5094) Summary: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(18521) poly(rC) binding protein 2
- Rat(363005) poly(rC) binding protein 2
- naked mole-rat(101702918) poly(rC) binding protein 2
- Zebrafish(321844) poly(rC) binding protein 2
- dog(477596) poly(rC) binding protein 2
- domestic cat(101086733) poly(rC) binding protein 2
- Horse(100062163) poly(rC) binding protein 2
- cow(540653) poly(rC) binding protein 2
- sheep(101103142) poly(rC) binding protein 2
- domestic guinea pig(100731593) poly(rC) binding protein 2
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Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-PCBP2 (hnRNP E2) Antibody, clone PC81-1, clone PC 81-1, from mouse,
Reactividad de especies
human
Aplicación
immunocytochemistry
western blot
western blot
Anti-PCBP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
KD-Validated Anti PCBP2 Antibody, clone 23GB2110, Rabbit Monoclonal, clone 23GB2110, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reactividad de especies
human, rat
Aplicación
flow cytometry
immunofluorescence
western blot
immunofluorescence
western blot