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Merck

POLR2A

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Sinónimos:
POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1
Especie:
ID UniProtKB:
ID del gen:
  • Human(5430) Summary: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
  • Mouse(20020) polymerase (RNA) II (DNA directed) polypeptide A
  • Rat(363633) polymerase (RNA) II (DNA directed) polypeptide A
  • cow(282312) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • naked mole-rat(101725588) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • dog(479483) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • Zebrafish(553347) polymerase (RNA) II (DNA directed) polypeptide A
  • sheep(100144762) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • domestic cat(101098500) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • domestic guinea pig(100734232) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Custom & Knockdown Gene Products

Antibodies

Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-phospho RNA Pol II (Ser5), clone 1H4B6 Antibody, clone 1H4B6, from rat,
Reactividad de especies
canine, human, monkey, mouse, rat
Aplicación
ChIP
ELISA

immunocytochemistry

western blot
Anti-phospho RNA Pol II (Ser2), clone 3E7C7 Antibody, clone 3E7C7, from rat,
Reactividad de especies
canine, human, monkey, mouse, rat
Aplicación
ChIP
ELISA

immunocytochemistry

western blot
Anti-POLR2A Antibody, clone 3G21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
immunohistochemistry

western blot
Anti-POLR2A Antibody, clone 1F5, clone 1F5, from rat,
Reactividad de especies
human
Aplicación
ChIP
immunocytochemistry

western blot
Anti-phospho RNA Pol II (Ser7), clone 3D4A12 Antibody, clone 3D4A12, 1 mg/mL, from rat,
Reactividad de especies
canine, human, monkey, mouse, rat
Aplicación
ChIP
ELISA

immunocytochemistry

western blot

Proteins

Número de producto
Descripción
Especie
RNA Polymerase II, C-terminal human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
Especie
human
RNA Polymerase II, C-terminal domain, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Especie
human

esiRNA

Número de producto
Descripción
Especie
MISSION® esiRNA, targeting human POLR2A,
Especie
human
MISSION® esiRNA, targeting mouse Polr2a,
Especie
mouse