UMOD
uromodulin
Sinónimos:
ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP
Especie:
Human UMOD (7369), Mouse Umod (22242), Rat Umod (25128), sheep UMOD (101119604), dog UMOD (403510), domestic guinea pig Umod (100730507), cow UMOD (281567), domestic cat UMOD (101084248), naked mole-rat Umod (101709895)
ID UniProtKB:
ID del gen:
- Human(7369) Summary: The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- Mouse(22242) uromodulin
- Rat(25128) uromodulin
- sheep(101119604) uromodulin
- dog(403510) uromodulin
- domestic guinea pig(100730507) uromodulin
- cow(281567) uromodulin
- domestic cat(101084248) uromodulin
- naked mole-rat(101709895) uromodulin
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Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-Uromodulin/THP, ,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Proteins
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esiRNA
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