CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Synonyme:
CILP-1, HsT18872
Spezies:
Human CILP (8483), Mouse Cilp (214425), Rat Cilp (315761), Zebrafish cilp (553329), cow CILP (100336614), Horse CILP (100053337), domestic cat CILP (101084795), dog CILP (487603), sheep CILP (101119218), chicken CILP (415533) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(8483) Summary: Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
- Mouse(214425) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- Rat(315761) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- Zebrafish(553329) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- cow(100336614) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- Horse(100053337) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- domestic cat(101084795) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- dog(487603) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- sheep(101119218) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- chicken(415533) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- naked mole-rat(101723750) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
- domestic guinea pig(100721580) cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
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