DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
Synonyme:
DFF-45, DFF1, ICAD
Spezies:
Human DFFA (1676), Mouse Dffa (13347), Rat Dffa (114214), naked mole-rat Dffa (101700734), domestic guinea pig Dffa (100719233), sheep DFFA (101114715), cow DFFA (507981), domestic cat DFFA (101096745), chicken DFFA (419451), Zebrafish dffa (436904)
UniProtKB-ID:
Gen-ID:
- Human(1676) Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(13347) DNA fragmentation factor, alpha subunit
- Rat(114214) DNA fragmentation factor, alpha subunit
- naked mole-rat(101700734) DNA fragmentation factor, 45kDa, alpha polypeptide
- domestic guinea pig(100719233) DNA fragmentation factor, 45kDa, alpha polypeptide
- sheep(101114715) DNA fragmentation factor, 45kDa, alpha polypeptide
- cow(507981) DNA fragmentation factor, 45kDa, alpha polypeptide
- domestic cat(101096745) DNA fragmentation factor, 45kDa, alpha polypeptide
- chicken(419451) DNA fragmentation factor, 45kDa, alpha polypeptide
- Zebrafish(436904) DNA fragmentation factor, alpha polypeptide
- dog(487449) DNA fragmentation factor, 45kDa, alpha polypeptide
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-DFFA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab3,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
western blot
Anti-DFFA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
western blot
Anti-DFFA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Monoclonal Anti-DFFA, (C-terminal) antibody produced in mouse, clone 3A11, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
proximity ligation assay
western blot
proximity ligation assay
western blot
Anti-DFFA antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
immunofluorescence
western blot
western blot