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C3250000

Cyclophosphamid

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

Cyclophosphamid Monohydrat, 2-[Bis-(2-chlorethyl)-amino]-tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxid, Cytoxan

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Über diesen Artikel

Empirische Formel (Hill-System):
C7H15Cl2N2O2P · H2O
CAS-Nummer:
Molekulargewicht:
279.10
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4678992
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grade

pharmaceutical primary standard

API family

cyclophosphamide

manufacturer/tradename

EDQM

mp

49-51 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1

InChI

1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

InChI key

PWOQRKCAHTVFLB-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cyclophosphamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Cyclophosphamid ist ein Stickstofflostderivat, das in der Krebstherapie verbreitete Anwendung findet. Es führt zur Quervernetzung der DNA sowie zum Abbruch von Strängen und induziert Mutationen. Seine klinische Aktivität wird mit einer Abnahme der ALDH1-Aktivität (Aldehyd-Dehydrogenase 1) assoziiert.
Stickstofflostderivat, das in der Krebstherapie verbreitete Anwendung findet. Es führt zur Quervernetzung der DNA sowie zum Abbruch von Strängen und induziert Mutationen.

Packaging

Dieses Produkt wird, wie von der entsprechenden Pharmakopöe geliefert, angeboten. Die aktuellen Mengeneinheiten finden Sie im Referenzsubstanzen-Katalog der EDQM.

Other Notes

Sales restrictions may apply.

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Dieser Artikel
BP1094PHR140493813
Cyclophosphamid British Pharmacopoeia (BP) Reference Standard

BP1094

Cyclophosphamid

description

European Pharmacopoeia (EP) Reference Standard

description

British Pharmacopoeia (BP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

analytical standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

analytical standard

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

-

manufacturer/tradename

-

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

application(s)

forensics and toxicology
veterinary

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

API family

cyclophosphamide

API family

cyclophosphamide

API family

cyclophosphamide

API family

-


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pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3



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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. ¿Para poder resuspender el producto, se podría usar PBS?

    1 answer
    1. This is a product of the European Pharmacopoeia. Solubility information is not provided by the supplier. However, the research grade product C0768 is the same compound and the solubility information may be applied to the EP standard. The compound is soluble in water at 40mg/mL. Please see the following link for the product information : https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/268/329/c0768pis.pdf

      Please see this link to contact EP directly:
      https://crs.edqm.eu/db/4DCGI/View=C3250000

      Helpful?

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