[Direkt zum Inhalt](https://www.sigmaaldrich.com#main-content) [![Merck](https://www.sigmaaldrich.com/static/logos/purple/merck.svg)](https://www.sigmaaldrich.com/AT/de) Produkte Warenkorb0 ATDE Produkte ProdukteAnwendungenDienstleistungenRessourcenUnterstützung [Anmelden / Registrieren](https://www.sigmaaldrich.com/oidc-sign-in) [Bestellungssuche](https://www.sigmaaldrich.com/AT/de/order-lookup) [Schnelleinkauf](https://www.sigmaaldrich.com/AT/de/quick-order) Warenkorb0 [Home](https://www.sigmaaldrich.com/AT/en)[Next-Generation Sequencing](https://www.sigmaaldrich.com/AT/en/applications/genomics/next-gen-sequencing)Positive Control siRNA # Positive Control siRNA MISSION® Positive Control siRNA serve as an ideal complement to any gene silencing experiment. Positive controls are validated siRNA known to achieve high levels (>70%) of knockdown. A positive control should be used to optimize transfection, and if it fails to produce the expected phenotype, adjustments to experimental conditions are likely necessary. ## Product Benefits - Best-in-class, [guaranteed](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/gene-expression-and-silencing/mission-sirna-faq) gene silencing - Knockdown efficiencies [validated](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/gene-expression-and-silencing/mission-sirna-faq) to be ≥75% - Designed with the Rosetta algorithm* \*The proprietary Rosetta Inpharmatics siRNA Design algorithm is licensed in an exclusive partnership with Merck​. The Rosetta siRNA Design Algorithm utilizes Position-Specific Scoring Matrices and knowledge of the seed region to predict the most specific and effective sequences for your target genes. The algorithm’s rules were developed utilizing empirical data collected from gene silencing experiments carried out over three years. ## Product Features - Species: Human & Rat - Quantities: 2 (10 nmol), 5 (25 nmol) & 10 (50 nmol) OD - Purification: Desalt or HPLC - Sequence Form: 21mer duplexes with dTdT overhangs - Modifications: None (natural RNA bases only) - Quality Control: 100% mass spectrometry* - Format: Supplied dry in tubes \*Depending on manufacturing site, PAGE may be used to assess siRNA duplexes | | | | |----------------------------------|-------------|--------------------------------------------------------------------------| | Available Positive Control siRNA | | | | __Gene__ | __Species__ | | | GAPDH | Human & Rat | [Order Now](https://www.sigmaaldrich.com/AT/en/semi-configurators/sirna) | | MAPK1 | Human & Rat | [Order Now](https://www.sigmaaldrich.com/AT/en/semi-configurators/sirna) | | KIF11 | Human | [Order Now](https://www.sigmaaldrich.com/AT/en/semi-configurators/sirna) | | LMNA | Human & Rat | [Order Now](https://www.sigmaaldrich.com/AT/en/semi-configurators/sirna) | | PPIB | Human & Rat | [Order Now](https://www.sigmaaldrich.com/AT/en/semi-configurators/sirna) | | TP53 | Human & Rat | [Order Now](https://www.sigmaaldrich.com/AT/en/semi-configurators/sirna) | If additional help is needed, please consult our technical services group at [oligotechserv@sial.com](mailto:oligotechserv@sial.com). MISSION is a trademark of Merck KGaA, Darmstadt, Germany, and/or its affiliates. [Label License](https://www.sigmaaldrich.com/AT/en/life-science/legal/product-licenses/mission-rnai-licenses). Bitte entschuldigen Sie, es ist ein unerwarteter Fehler aufgetreten Response not successful: Received status code 500 __Related Technical Articles__ - [Cas9-Mediated Recombineering for Kdo2-Lipid A](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/advanced-gene-editing/crispr-cas-systems) - [Plasmid Product Nomenclature](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/cloning-and-expression/plasmid-nomenclature) - [Benzonase® Nuclease for Microbiome Workflows](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/dna-and-rna-purification/benzonase-nuclease-microbiome-workflows) - [Impact of GenElute™-E Purification on DNA Processes](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/dna-and-rna-purification/dna-purification-methods) - [Extract-N-Amp™ Plant PCR Kits](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/dna-and-rna-purification/extract-n-amp-plant-kits) - [MetaPolyzyme, DNA Free Cell Lysis Enzymes for Microbiome Workflows](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/dna-and-rna-purification/metapolyzyme-dna-free-cell-lysis-enzymes-for-microbiome-workflows) - [Ultrapure vs. DEPC Treated Water for Molecular Biology Applications](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/dna-and-rna-purification/nuclease-free-water) - [Genomic DNA Preparation Troubleshooting](https://www.sigmaaldrich.com/AT/en/technical-documents/technical-article/genomics/dna-and-rna-purification/problems-during-genomic-dna-preparation) - [View More](https://www.sigmaaldrich.com/AT/en/search/facet-search?focus=sitecontent&term=facet-search) __Related Product Categories__ - [Custom DNA Oligos & qPCR Probes](https://www.sigmaaldrich.com/AT/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-predesigned-dna-oligos-and-qpcr-probes) - [Custom & Predesigned RNA Oligos, siRNA Duplexes and Controls](https://www.sigmaaldrich.com/AT/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-predesigned-rna-oligos-sirna-duplexes-controls) Oben __Melden Sie sich an, um fortzufahren.__ Um weiterzulesen, melden Sie sich bitte an oder erstellen ein Konto. 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