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Merck

NEFL

neurofilament, light polypeptide

Synonyms:
CMT1F, CMT2E, NF-L, NF68, NFL
Species:
UniProtKB ID:
Gene ID:
  • Human(4747) Summary: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
  • Mouse(18039) neurofilament, light polypeptide
  • Rat(83613) neurofilament, light polypeptide
  • chicken(419528) neurofilament, light polypeptide
  • sheep(101119539) neurofilament, light polypeptide
  • cow(281348) neurofilament, light polypeptide
  • dog(477378) neurofilament, light polypeptide
  • naked mole-rat(101704332) neurofilament, light polypeptide
  • domestic cat(101081039) neurofilament, light polypeptide
  • domestic guinea pig(100731797) neurofilament, light polypeptide

Custom & Knockdown Gene Products

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Neurofilament 68 antibody produced in mouse, clone NR4, ascites fluid,
Species Reactivity
chicken, human, pig, rat
Application
immunohistochemistry
microarray

western blot
Anti-Neurofilament L Antibody, clone 1E13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-Neurofilament L Antibody, serum, Chemicon®,
Species Reactivity
bovine, canine, feline, human, mouse, pig, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-Neurofilament 70 kDa Antibody, clone DA2, culture supernatant, clone DA2, Chemicon®,
Species Reactivity
bovine, human, mouse, pig, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-NEFL antibody produced in mouse, clone 2G10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot

Proteins

Product Number
Description
Species
Neurofilament 70 kDa, porcine, ,
Species

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NEFL,
Species
human