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Merck

PRMT6

protein arginine methyltransferase 6

Synonyms:
HRMT1L6
Species:
UniProtKB ID:
Gene ID:
  • Human(55170) Summary: The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
  • Mouse(99890) protein arginine N-methyltransferase 6
  • Rat(295384) protein arginine methyltransferase 6
  • domestic cat(101093626) protein arginine methyltransferase 6
  • domestic guinea pig(100725259) protein arginine methyltransferase 6
  • cow(540228) protein arginine methyltransferase 6
  • Thale Cress(821541) protein arginine N-methyltransferase 6
  • naked mole-rat(101715374) protein arginine methyltransferase 6
  • sheep(101119859) protein arginine methyltransferase 6
  • Zebrafish(448867) protein arginine methyltransferase 6
  • dog(490133) protein arginine methyltransferase 6

Custom & Knockdown Gene Products

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PRMT6 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, pig, rat
Application
ELISA
western blot
Anti-PRMT6 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rat
Application
ChIP
western blot
Anti- PRMT6 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-PRMT6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-PRMT6 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, rat
Application
western blot

Proteins

Product Number
Description
Species
PRMT6 active human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
PRMT6 human, recombinant, expressed in FreeStyle 293-F cells, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PRMT6,
Species
human
MISSION® esiRNA, targeting mouse Prmt6,
Species
mouse