U1006

Uridine 5′-triphosphate trisodium salt solution

HPLC purified, aqueous solution for RNA polymerase transcription

• Synonym(s): UTP
• NACRES: NA.52
• PubChem Substance ID: 24900622
• UNSPSC Code: 41106305
• MDL number: MFCD00044310
• Assay: ≥95 (HPLC)
• Biological source: yeast (Candida Utilis)
• Form: liquid
• Storage temp.: −20°C

Properties

• InChI: 1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1
• SMILES string: [Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O
• InChI key: MMJGIWFJVDOPJF-LLWADOMFSA-K
• biological source: yeast (Candida Utilis)
• assay: ≥95 (HPLC)
• form: liquid
• concentration: 100 mM in H₂O (adjusted to pH 7 with Trizma^®; base)
• Quality Level: 300
• Gene Information: human ... P2RY2(5029) ; rat ... P2ry2(29597)
• technique(s): cDNA synthesis: suitable
• color: colorless
• foreign activity: DNase and RNase, none detected
• shipped in: dry ice
• storage temp.: −20°C

Description

Application

Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca²⁺ levels in rat primary tracheal epithelial cells.[1] It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).[2]

Biochem/physiol Actions

P2Y receptor agonist

UTP plays a crucial role in the process of transcription by participating in the synthesis of RNA.[3] It is associated with glycogen synthesis, protein glycosylation, and membrane phospholipid biosynthesis.[4] UTP is involved in the production of ATP, which is essential for metabolic reactions.[3]

Uridine 5′-triphosphate (UTP) is released during nerve injury and acts as an agonist of the purinergic P2Y2 receptors present on the surface of Schwann cells.

Legal Information

Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable