Small molecule HPLC

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Showing 1-30 of 185 results

Cannabinoid CRMs: Testing Accuracy & Traceability

ISO-certified cannabinoid CRMs, THC and THCA, available as single components or mixes, for accurate potency testing.

Isotopically Labeled Steroid Standards

Anabolic steroid testing remains crucial in competitive sports to maintain fairness.

Synthetic Cannabinoid Analysis

A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.

Universal Hydrophilic Syringe Filters: Millex^®

Millex® hydrophilic PTFE syringe filters offer broad chemical compatibility and robust performance for various sample filtrations.

Bioethanol

Learn more about Bioethanol as a renewable, alternative fuel traditionally produced by the yeast fermentation of sugar.

SupraSolv® GC Solvent Specifications

Our GC solvents have been specially developed and tested for ECD, FID and MS detection or for headspace gas chromatography to ensure accurate, reliable and reproducible analytical results.

Application Note – Peroxidase in Vegetables

Application Note: Peroxidase in vegetables – Visual determination after conversion of a specific substrate.

Ascentis® Express Biphenyl UHPLC and HPLC Columns

The bonded, densely endcapped, dimethyl-biphenyl stationary phase of Ascentis® Express 90 Å Biphenyl, based on fused-core particles, provides a stable, reversed phase packing with enhanced π-π and mild steric interactions due to the two sequential phenyl groups bonded to the

Ascentis^® Express Peptide ES-C18 U/HPLC Columns

Choose Ascentis® Express Peptide ES-C18 U/HPLC Columns based on Fused-Core® technology for fast and efficient separation of high-molecular weight compounds, such as peptides and small proteins. With a 2.7 µm particle size and rigorous testing, these columns offer reliable results

Ascentis® Express C8 U/HPLC Columns

When a C18 doesn′t give the desired separation, or your sample contains compounds that are known to be difficult to retain or resolve on a C18, consider changing to an Ascentis® Express C8 column.

Ascentis® Express F5 (Pentafluorophenyl) U/HPLC Columns

Enhanced selectivity for stereoisomers and closely related compounds with alternate selectivity from C18 phases for basic, acidic, or neutral compounds

Derivatization Agents for LC/MS – An Improved Detection of Estradiol with ESI-MS

Improved LC/MS Detection of Estradiol using 4-(Dimethylamino) benzoyl chloride (DMABC) derivatization agent relative to dansyl chloride.

Detection, Measurement and Regulation of NOGE (Novolac Glycidyl Ethers) and Other Packaging-Derived Epoxy Compounds In Food Products

Ephedrine/Pseudoephedrine HCl in Oral Solution Analysis

HPLC method on Purospher® RP-18e column analyzes ephedrine and pseudoephedrine HCl in traditional Chinese medicine.

Fast Separation of 18 PAHs with Ascentis^® Express

Ascentis® Express PAH column efficiently separates polynuclear aromatic hydrocarbons in EPA methods.

HPLC Products for Any LC Instrument

Explore our extensive HPLC column range compatible with systems from any vendor for specialized applications.

HybridSPE-Phospholipid Technology

This Sigma-Aldrich article discusses how the HybridSPE-Phospholipid Technology works and how the phospholipids are removed.

Improving USP Lansoprazole Analysis with HPLC

USP methods continuously revised for modernization and improved results in drug testing.

Impact of Mobile Phase Additives on LC-MS Sensitivity, Demonstrated using Spice Cannabinoids

This study demonstrates the impact of various mobile phase modifiers on the separation; formate modifiers outperform acetate in terms of MS signals (or sensitivity) and chromatographic resolution.

LiChrospher^® HPLC Columns

Discover LiChrospher® HPLC Columns with spherical silica-based sorbents, offering diverse modifications to meet a wide range of needs in normal and reversed-phase HPLC.

UHPLC Analysis of Cannabinoids

Cannabis products need cannabinoid characterization. Ascentis Express C18 resolves 14 similar cannabinoids in under seven minutes with excellent peak shape.

UHPLC Analysis of Diclofenac in Gel using a Monolithic Silica Column

A comparative UHPLC analysis of diclofenac sodium in gel using Chromolith® HighResolution RP-18 endcapped 100 x 2 mm I.D column and FPP 1.7 µm hybrid silica C18 100 x 2.1 mm I.D column with UV and MS detection.

UHPLC Analysis of Nucleosides on Supel™ Carbon LC Column: Performance Comparisons with Competitor

Ultra-high performance liquid chromatographic (UHPLC) separation of 12 nucleosides using Supel™ Carbon LC column in 15 minutes for use in identification and quantitation of nucleoside biomarkers.

UHPLC Analysis of Paraquat and Diquat on Supel™ Carbon LC

Ultra-high performance liquid chromatographic (UHPLC) separation of polar herbicides, paraquat and diquat using SupelTM Carbon LC column with baseline resolution, excellent peak shape, and good lot-to-lot reproducibility.

USP HPLC Analysis of L-Methionine on Ascentis® Express OH5

Separation of L-Methionine, Pharmaceutical Secondary Standard; Certified Reference Material

USP HPLC Columns

Explore our full selection of USP HPLC columns, from L1 to L45, made for accurate and reliable separations in a wide range of applications.

LC/MS/MS Method for Determination of Glyphosate, AMPA, and Glufosinate in Cereals

Glyphosate and related compounds are measured in oatmeal and infant cereal using ion-exchange polymer-based particles for HPLC and SPE. Low level detection was obtained.

Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

Novel sample prep technique coupled with the unique selectivity of the Ascentis Express F5 column enables a fast and simplified bioanalytical method for associated vitamin D metabolites.

Two Distinct Sample Prep Approaches to Overcome Matrix Effect in LC/MS of Serum or Plasma Samples

This article highlights the impact that sample matrix effects can have on LC/MS response and discusses two novel approaches to reduce it.

Solid Phase Extraction for Aflatoxin Analysis

Supel Tox AflaZea SPE improves analyte recovery with less sample volume, while HPLC confirms effective elimination of interferences.

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