- Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives.
Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives.
Bioorganic & medicinal chemistry letters (2005-11-18)
Bin Zhu, Brett A Marinelli, Darren Abbanat, Barbara D Foleno, Todd C Henninger, Karen Bush, Mark J Macielag
PMID16289812
ABSTRACT
A series of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives has been synthesized. Several functional groups were identified as the optimal C3-substituents, and the best compounds in this series possess potent in vitro antibacterial activity against erythromycin-susceptible and erythromycin-resistant bacteria.