Synthesis, structure and pharmacology of acyl-2,6-xylidines.

Synthesis, structure and pharmacology of acyl-2,6-xylidines.

Acta poloniae pharmaceutica (2004-10-16)

Włodzimierz Białasiewicz, Wincenty Kwapiszewski, Elzbieta Zurek, Andrzej Olczak, Marek Główka, Rościsław Polakowski

ABSTRACT

L-2-perhydroheterocyclicalkyl acids were condensed with 2,6-xylidine. 8 new optically active acyl-2,6-xylidines were obtained. Absolute configuration of acyl-2,6-xylidines were selected for pharmacological examinations.

MATERIALS

Product Number

Brand

Product Description

T0202

Sigma-Aldrich

Tocainide hydrochloride, ≥98% (HPLC), solid

36766

Supelco

2,6-Dimethylaniline, PESTANAL^®, analytical standard

D146005

Sigma-Aldrich

2,6-Dimethylaniline, 99%

442327

Supelco

2,6-Dimethylaniline, analytical standard