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26454

Sigma-Aldrich

Magnesium stearate

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

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Synonym(s):
Stearic acid magnesium salt
Linear Formula:
[CH3(CH2)16CO2]2Mg
CAS Number:
Molecular Weight:
591.24
Beilstein:
3919702
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.22

grade

puriss.

Assay

≥40% stearic acid basis (GC)
≥90% stearic and palmitic acid basis
4.0-5.0% Mg basis (calc on dry sub.)

quality

meets analytical specification of Ph. Eur., BP

impurities

acidity or alkalinity, complies
microbiological impurity, in accordance
residual solvents, complies

loss

≤6.0% loss on drying, 105 °C

mp

200 °C (lit.)

acid value

195‑210(fatty acid)

solubility

alcohol: insoluble
diethyl ether: insoluble
water: insoluble

anion traces

chloride (Cl-): ≤1000 mg/kg
sulfate (SO42-): ≤5000 mg/kg

cation traces

Cd: ≤3 mg/kg
Ni: ≤5 mg/kg
Pb: ≤10 mg/kg

suitability

in accordance for fatty acid composition
passes test for identity

application(s)

pharmaceutical (small molecule)

SMILES string

CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2

InChI key

HQKMJHAJHXVSDF-UHFFFAOYSA-L

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Application

Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules.

Biochem/physiol Actions

Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Journal of Raman Spectroscopy, 40 (2008)
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International journal of pharmaceutics, 475(1-2), 462-470 (2014-09-01)
Clinical performance of an amorphous solid dispersion (ASD) drug product is related to the amorphous drug content because of the greater bioavailability of this form of the drug than its crystalline form. Therefore, it is paramount to monitor the amorphous
Julia Grund et al.
International journal of pharmaceutics, 469(1), 94-101 (2014-04-22)
The objective of this study was to identify and evaluate key polymer properties affecting direct compression and drug release from water-insoluble matrices. Commonly used polymers, such as Kollidon(®) SR, Eudragit(®) RS and ethyl cellulose, were characterized, formulated into tablets and
A Kluk et al.
International journal of pharmaceutics, 485(1-2), 1-6 (2015-03-05)
Minitablets are a novel, multi-compartment solid drug formulation, particularly intended for children between 1 and 6 years of age. Available literature shows that even infants are capable of swallowing a single minitablet. In this study, we have explored the level

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