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Merck

F7

coagulation factor VII (serum prothrombin conversion accelerator)

Synonymes:
SPCA
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(2155) Summary: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
  • Mouse(14068) coagulation factor VII
  • Rat(260320) coagulation factor VII (serum prothrombin conversion accelerator)
  • naked mole-rat(101706917) coagulation factor VII (serum prothrombin conversion accelerator)
  • domestic guinea pig(100727155) coagulation factor VII (serum prothrombin conversion accelerator)
  • fruit fly(5657732) f7
  • Zebrafish(114423) coagulation factor VII
  • chicken(395086) coagulation factor VII (serum prothrombin conversion accelerator)
  • dog(607661) coagulation factor VII (serum prothrombin conversion accelerator)
  • domestic cat(101090581) coagulation factor VII (serum prothrombin conversion accelerator)
  • cow(617960) coagulation factor VII (serum prothrombin conversion accelerator)
  • sheep(101118369) coagulation factor VII (serum prothrombin conversion accelerator)
  • Domestic Rabbit(100009399) coagulation factor VII (serum prothrombin conversion accelerator)

Custom & Knockdown Gene Products

ELISA

Numéro du produit
Description
Espèce(s)
Human Coagulation Factor VII ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Espèce(s)
human

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti-Factor VII antibody, Mouse monoclonal, clone HVII-1, purified from hybridoma cell culture,
Espèces réactives
human
Application
ELISA
western blot
Anti-FA7 (light chain, Cleaved-Arg212) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
immunohistochemistry

western blot

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse F7,
Espèce(s)
mouse
MISSION® esiRNA, targeting human F7,
Espèce(s)
human