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DRD2

dopamine receptor D2

Synonyms:

D2DR, D2R

Species:

Human DRD2 (1813), Mouse Drd2 (13489), Rat Drd2 (24318), dog DRD2 (403701), Domestic Rabbit DRD2 (100347371), Horse DRD2 (100062195), naked mole-rat Drd2 (101711462), sheep DRD2 (101113525), chicken DRD2 (428252), domestic guinea pig Drd2 (100732584) ...More

UniProtKB ID:

P14416, Q9NZR3, Q9UPA9

Gene ID:

Human(1813) Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Mouse(13489) dopamine receptor D2
Rat(24318) dopamine receptor D2
dog(403701) dopamine receptor D2
Domestic Rabbit(100347371) dopamine receptor D2
Horse(100062195) dopamine receptor D2
naked mole-rat(101711462) dopamine receptor D2
sheep(101113525) dopamine receptor D2
chicken(428252) dopamine receptor D2
domestic guinea pig(100732584) dopamine receptor D2
cow(281126) dopamine receptor D2
domestic cat(101096838) dopamine receptor D2

Products (53)
Peer Reviewed Papers (838)

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Small Molecule - Agonist

Product Number

Description

Species

Cabergoline, European Pharmacopoeia (EP) Reference Standard,

Species

human

P102

R(+)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride, solid,

Species

human

Cabergoline, ≥98% (HPLC),

Species

human

Q102

(−)-Quinpirole hydrochloride, ≥98% (HPLC), solid,

Species

human

Bifeprunox mesylate, ≥98% (HPLC),

Species

human

Small Molecule - Antagonist

Product Number

Description

Species

E101

S-(−)-Eticlopride hydrochloride, ≥98% (HPLC), powder,

Species

human

R121

S(−)-Raclopride (+)-tartrate salt, >97%, solid,

Species

human

Tyramine, ≥98.0%,

Species

rat

Iloperidone, ≥98% (HPLC),

Species

human

Metoclopramide, VETRANAL^®, analytical standard,

Species

human

Antibodies

Product Number

Description

Species Reactivity

Application

Anti-Dopamine D_2S Receptor Rabbit pAb, lyophilized, Calbiochem^®,

Species Reactivity

human, rat

Application

Anti-DRD2, affinity isolated antibody,

Species Reactivity

human

Application

immunohistochemistry

Anti-Dopamine D2 Receptor Antibody, from rabbit, purified by affinity chromatography,

Species Reactivity

mouse

Application

immunohistochemistry

Anti-Dopamine D2 Receptor Antibody, serum, Chemicon^®,

Species Reactivity

rat

Application

ELISA
immunocytochemistry
immunohistochemistry
western blot

Monoclonal Anti-DRD2, (N-terminal) antibody produced in mouse, clone 1B11, ascites fluid,

Species Reactivity

human

Application

ELISA
western blot

Small Molecule - Inhibitor

Product Number

Description

Species

D052

GBR 12909 dihydrochloride, solid, ≥98% (HPLC),

Species

human

I119

Indatraline hydrochloride, solid,

Species

human

α-Sexithiophene, ,

Species

human, rat

Harmaline, ≥95%,

Species

human, rat

2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,

Species

human, rat, mouse

Small Molecule - Ligand

Product Number

Description

Species

Cinnarizine, powder,

Species

human

Small Molecule - Metabolite

Product Number

Description

Species

3-Hydroxy-4-methoxyphenethylamine hydrochloride, ,

Species

human

3-Methoxytyramine hydrochloride, ≥95.5%, crystalline,

Species

human

Small Molecule - Precursor

Product Number

Description

Species

3,4-Dihydroxy-DL-phenylalanine, ,

Species

mouse, human, rat

3,4-Dihydroxy-L-phenylalanine, ≥98% (TLC),

Species

mouse, human, rat

esiRNA

Product Number

Description

Species

MISSION^® esiRNA, targeting human DRD2,

Species

human