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KITALYSIS-SM

Sigma-Aldrich

KitAlysis High-Throughput Suzuki-Miyaura Cross-Coupling Reaction Screening Kit - Pack of 4

Synonym(s):
Suzuki-Miyaura Cross-Coupling
NACRES:
NA.22

reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

functional group

phosphine

Application

Screening kit for Suzuki-Miyaura cross-coupling reaction. Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.
Step-by-Step Guide for Suzuki-Miyaura Cross-Coupling Reaction Screening Kit
Downloadable Experiment excel sheets.

Each kit contains 4 customizable screening sets that include the following components:
  • 6 x 4 pre-weighed catalysts in glass vials loaded with stir bars and topped with cap mat.
  • 1 (2 mL) ampule each of Toluene, THF, n-Butanol, DMAc, and aq. 1.5 M K3PO4.
  • 4 NEW KitAlysis 24-Well Reaction Block Replacement Films.
  • 4 substrate reaction vials with stir bars.
  • 1 internal standard.

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists.
  • Easily run 24-microscale reactions in parallel.
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration.
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks.

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit Components Also Available Separately

Product No.
Description
SDS

  • 732117Pd-PEPPSI-IPent catalyst, ≥95% 5 µmol

  • 753009SPhos Pd G2 5 µmol

  • 761311cataCXium® A Pd G2 5 µmol

  • 763381XPhos Pd G3, 98% 5 µmol

  • 764175P(Cy3) Pd G3, 97% 5 µmol

  • 764183APhos Pd G3, 97% 5 µmol

  • 900522Toluene, anhydrous, ZerO2®, 99.8% 8 mL

  • 900636Tetrahydrofuran, anhydrous, inhibitor-free, ZerO2®, ≥99.9% 8 mL

  • 9006391-Butanol, anhydrous, ZerO2®, 99.8% 8 mL

  • 900634N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mL

  • Degassed Potassium phosphate tribasic solution 8 mL

  • Z118850Spinbar® magnetic stirring fleas, red, L 10 mm, diam. 3 mm 1 EA

  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

See All (13)

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 2

Target Organs

Central nervous system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

Flash Point(F)

1.4 °F

Flash Point(C)

-17 °C

Certificate of Analysis

Certificate of Origin

Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Karl D Collins et al.
Nature chemistry, 6(10), 859-871 (2014-09-23)
New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical...
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in...

Articles

Scale-Up Guide: Suzuki-Miyaura Cross-Coupling Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form.

KitAlysis™ High-Throughput Screening Platform

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

KitAlysis™ Suzuki-Miyaura Cross-Coupling Reaction Screening Kit

Multiple tools have been created to ensure your success with kit set up. Start with the more detailed guide to ensure you are comfortable with all of the steps before using the quick guides on the excel worksheet. Remember that while the technique is new, it is still organic chemistry and so the steps will seem easy once you try just one kit. It is just a new way of approaching something you are already very good at.

KitAlysis High-Throughput Palladium Precatalyst Cross-Coupling Reaction Screening Kit

Materials Included in your KITALYSIS-24PD-2PK High-Throughput Screening Kit

Protocols

Step-by-Step Guide for KitAlysis™ Suzuki-Miyaura Cross-Coupling Reaction Screening Kit

A step-by-step protocol guide for KitAlysis Suzuki-Miyaura Cross-Coupling Reaction Screening Kit.

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