Merck
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QBD10200

Sigma-Aldrich

NHS-dPEG®4-biotin

Empirical Formula (Hill Notation):
C25H40N4O10S
CAS Number:
Molecular Weight:
588.67
PubChem Substance ID:
NACRES:
NA.22

assay

>90%

form

solid or viscous liquid

reaction suitability

reaction type: Biotinylations
reactivity: amine reactive

reagent type: cross-linking reagent

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCNC(CCCCC2C3NC(NC3CS2)=O)=O

Features and Benefits

NHS-dPEG®4-biotin is used extensively to label molecules that contain a free amine with biotin. The single molecular weight NHS-dPEG®4-biotin has a long spacer of precise length (19.2 Å) between the biotin moiety and the labeled molecule. This dPEG® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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