27285

Ethylenediaminetetraacetic acid disodium salt dihydrate

meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

• Synonym(s): Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na₂, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na₂
• Empirical Formula (Hill Notation): C₁₀H₁₄N₂Na₂O₈ · 2H₂O
• CAS Number: 6381-92-6
• Molecular Weight: 372.24
• Beilstein: 3900609
• EC Number: 205-358-3
• PubChem Substance ID: 24856480
• NACRES: NA.77

Properties

• Agency: tested according to BP; tested according to Ph. Eur.; tested according to USP
• Quality Level: 200
• reg. compliance: tested according to FCC
• assay: 99.0-101.0%
• quality: meets analytical specification of Ph. Eur., BP, USP, FCC
• impurities: residual solvents, complies; ≤0.001% cyanide (CN); ≤0.001% heavy metals (as Pb); ≤0.1% nitrilotriacetic acid (HPLC) (HPLC)
• loss: 8.7-11.4% loss on drying, 200 °C, 3 h
• pH: 4-5 (20 °C, 5%)
• mp: 248 °C (dec.) (lit.)
• solubility: water: soluble 100 g/L at 20 °C
• anion traces: chloride (Cl^-): ≤100 mg/kg; sulfate (SO₄^2-): ≤500 mg/kg
• cation traces: As: ≤1 mg/kg; Ca:, in accordance; Fe: ≤10 mg/kg; Pb: ≤10 mg/kg
• application(s): pharmaceutical (small molecule)
• SMILES string: O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O
• InChI: 1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
• InChI key: OVBJJZOQPCKUOR-UHFFFAOYSA-L

Description

Application

Ethylenediaminetetraacetic acid disodium salt dihydrate has been used along with Na₂HPO4 and citric acid for preparing Na₂EDTA-McIlvaine buffer. Aqueous solution of Ethylenediaminetetraacetic acid disodium salt dihydrate has also been used for photocatalytic hydrogen production

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Packaging

500 g

1, 1, 25 kg

Biochem/physiol Actions

Ethylenediaminetetraacetic acid disodium salt dihydrate is a widely used chelator of divalent cations like Ca⁺² and inhibits metal ion-dependent proteases such as calcium-dependent cysteine proteases. EDTA also acts as a chelator of the zinc ion in the active site of metalloproteases; thus it inhibits metalloproteases that requires zinc for activity. Additionally, EDTA prevents platelet aggregation and is a preferred anticoagulant for platelet counts.

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Warning
• Hazard Statements: H332 - H373
• Precautionary Statements: P260 - P271 - P304 + P340 + P312 - P314 - P501
• Hazard Classifications: Acute Tox. 4 Inhalation - STOT RE 2 Inhalation
• Target Organs: Respiratory Tract
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves