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Butylated Hydroxytoluene

Pharmaceutical Secondary Standard; Certified Reference Material

2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, DBPC, Butylated hydroxytoluene, Butylhydroxytoluene, BHT
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:
E Number:

Quality Level


certified reference material
pharmaceutical secondary standard

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)


current certificate can be downloaded

autoignition temp.

878 °F


HPLC: suitable
gas chromatography (GC): suitable


265 °C (lit.)


69-73 °C (lit.)

Featured Industry

Cleaning Products
Food and Beverages
Personal Care
Pharmaceutical (small molecule)



pharmacopeia traceability

traceable to PhEur B1215000
traceable to USP 1092708

SMILES string




InChI key


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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Butylated hydroxytoluene (BHT) is a phenolic antioxidant used as a food additive. It is frequently added to dried cereals, cooking oils and animal foods. BHT is also known to enhance the stability of pharmaceuticals, fat-soluble vitamins and cosmetics .


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAB3695 in the slot below. This is an example certificate only and may not be the lot that you receive.



Signal Word


Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids



Flash Point(F)

260.6 °F - open cup

Flash Point(C)

127 °C - open cup

Certificate of Analysis

Certificate of Origin

Reactivity of butylated hydroxytoluene.
Lambert CR, et al.
Free Radical Biology & Medicine, 21(3), 395-400 (1996)
Deliang Guo et al.
Science signaling, 2(101), ra82-ra82 (2009-12-17)
Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma, their clinical relevance is poorly understood. Studies of tumors from patients treated...
Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT).
H Witschi et al.
Pharmacology & therapeutics, 42(1), 89-113 (1989-01-01)
A M Malkinson
Environmental mutagenesis, 5(3), 353-362 (1983-01-01)
Although the average American's daily consumption of BHT can be measured in milligrams, there are numerous reports that BHT causes organ damage in laboratory animals. Only a few genotoxic effects of BHT have been reported, however, including mutagenicity in the...
Hiroya Okamoto et al.
Experimental dermatology, 21 Suppl 1, 5-7 (2012-06-01)
Pt nanoparticle is a strong reductant and has been used as an antioxidant in cosmetics and medicine. It was reported to have catalase-like activity, which converts hydrogen peroxide to water and oxygen. However, in this study, freshly prepared Pt nanoparticle...


HPLC Analysis of Phenolic Antioxidants on Ascentis® Express C18 2.7 μm

Phenolic Antioxidants are added to polyers for controlling their degradation process. Irgafos 168, Irganox 1010, Ethanox 330, Irganox 1076, BHT, and Irgafos 168 are often used as antioxidants to prevent the degradation of polypropylene polymer formulations. This HPLC method is for the quantitation of an additive or mix of additives in a polymeric material.

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