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Sodium hydroxide

ACS reagent, ≥97.0%, pellets

‘Caustic soda’
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


ACS reagent

vapor density

>1 (vs air)

vapor pressure

<18 mmHg ( 20 °C)
3 mmHg ( 37 °C)






cell culture | mammalian: suitable
titration: suitable


≤0.001% N compounds
≤0.02% NH4OH ppt.
≤1.0% Na2CO3


318 °C (lit.)


water: soluble 1,260 g/L at 20 °C


2.13 g/cm3 at 20 °C

anion traces

chloride (Cl-): ≤0.005%
phosphate (PO43-): ≤0.001%
sulfate (SO42-): ≤0.003%

cation traces

Fe: ≤0.001%
Hg: ≤0.1 ppm
K: ≤0.02%
Ni: ≤0.001%
heavy metals (as Ag): ≤0.002%

SMILES string




InChI key


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General description

Sodium hydroxide (NaOH) also known as caustic soda is a water soluble inorganic base with a wide range of industrial application such as titration, dissolution testing and in impinger to remove acidic gases. It participates in the oxidation of glycerol catalyzed by Au/charcoal or Au/graphite. It participates in solvent-free aldol condensation reaction.


Sodium hydroxide may be used as a base in titration methods, dissolution testing, for adjusting pH and in the impinger to remove acidic gases.
It may be used in the following processes:
  • Conversion of glycerol to glyceric acid in the presence of gold catalyst.
  • Palladium-catalyzed cross-coupling reaction between vinylalkoxysilanes and aryl bromides or chlorides to form styrenes.
Sodium hydroxide (NaOH) was used in the following processes:
  • Preparation of sodium 3,3′-bis(sulfonato)-4,4′-bis(chloroacetamido)azobenzene (BSBCA) that is utilized in protein cross-linking techniques.
  • Preparation of electrolyte solution to study the effect of electrolyte composition on the conversion of CO2 to CO by electrochemical reduction.
  • Preparation of CSK (cytoskeleton) buffer for the three-dimensional (3D) slide method of preserving the 3D chromatin structure of testicular germ cells.
  • Synthesis of ZSMs (zeolite socony mobils).
Sodium hydroxide may be employed for the deterimination of specific surface area of colloidal silica, via titration. It may be employed for the direct oxidation of sodium borohydride, which was investigated by cyclic and linear voltammetry, chronoamperometry and chronopotentiometry. It may be used to prepare citrate buffer and borate buffer. It may be used in the synthesis of :
  • alkylaryl amidosulfobetaines
  • (3 -[4-teroctylphenoxyethoxyethoxyethyl] dimethylammonio propane sulfonate (XOSB)
  • trisulfobetaines (TriSBn)


25, 500, 6×500 g in poly bottle
1, 2.5 kg in poly bottle
12, 25, 50 kg in poly drum

Legal Information

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC



Signal Word


Hazard Statements

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A

Storage Class Code

8B - Non-combustible, corrosive hazardous materials



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development.
Krishnamurthy VV, et al.
Journal of Visualized Experiments, 124, e55823-e55823 (2017)
Synthesis of zeolite socony mobil from blue silica gel and rice husk ash as catalysts for hydrothermal liquefaction.
Danardono AES and Mansur FA.
Journal of Engineering Science and Technology, 10(8), 982-993 (2015)
Satoshi H Namekawa
Journal of visualized experiments : JoVE, (83)(83), e50819-e50819 (2014-01-25)
During testicular germ cell differentiation, the structure of nuclear chromatin dynamically changes. The following describes a method designed to preserve the three-dimensional chromatin arrangement of testicular germ cells found in mice; this method has been termed as the three-dimensional (3D)
Selective oxidation of glycerol to glyceric acid using a gold catalyst in aqueous sodium hydroxide.
Carrettin S, et al.
Chemical Communications (Cambridge, England), 7, 696-697 (2002)
The First Fluoride-Free Hiyama Reaction of Vinylsiloxanes Promoted by Sodium Hydroxide in Water.
Alacid E &amp; Najera C
Advanced Synthesis & Catalysis, 348(15), 2085-2091 (2006)

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