G5146

D-(+)-Glucose

Hybri-Max^™, powder, BioReagent, suitable for hybridoma

• Synonym(s): Dextrose
• Empirical Formula (Hill Notation): C₆H₁₂O₆
• CAS Number: 50-99-7
• Molecular Weight: 180.16
• Beilstein: 1724615
• EC Number: 200-075-1
• MDL number: MFCD00063774
• PubChem Substance ID: 24895199
• NACRES: NA.75

Properties

• biological source: maize
• Quality Level: 200
• grade: Hybri-Max^™
• product line: BioReagent
• Assay: ≥99.5%
• form: powder
• technique(s): cell culture | hybridoma: suitable
• impurities: endotoxin, tested
• mp: 150-152 °C (lit.)
• solubility: H₂O: 2g + 15 mL (Tested)
• SMILES string: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChI key: WQZGKKKJIJFFOK-DVKNGEFBSA-N
• Gene Information: human ... PYGM(5837)

Description

General description

Glycogen phosphorylase (PYG) exists as brain and muscle isoform. It is expressed in astrocytes and neurons respectively. The PYGM gene is mapped to human chromosome 11q13.1.

Application

D-(+)-Glucose has been used in cell engineering. It has also been used to perform oral glucose tolerance test.

Biochem/physiol Actions

Glycogen phosphorylase, muscle associated (PYGM), is an important contributor to glycogenolysis. Down regulation of PYGM gene is observed in schizophrenia. Mutation in PYGM leads to McArdle disease, a glycogen storage disorder. The PYGM gene is significantly associated with energy production.

Preparation Note

The material may produce a yellowish solution if prepared at a higher concentration than 2g + 15ml.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves