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P4458
Penicillin-Streptomycin
liquid, non-animal origin, suitable for cell culture, BioReagent
Penicillin-Streptomycin
1 of 1 reviewers received a sample product or took part in a promotion
Synonym(s):
Pen-Strep
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Product Name
Penicillin-Streptomycin, Solution Stabilized, with 5,000 units penicillin and 5mg streptomycin/mL, 0.1 μm filtered, BioReagent, suitable for cell culture
SMILES string
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O.CNC[C@H]4[C@H](O)[C@@H](O)[C@H](CCO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)C5(O)C=O)O[C@H]6[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]6NC(N)=N
InChI
1S/C23H43N7O12.C16H18N2O4S/c1-7-23(38,6-32)18(42-19-8(5-28-2)12(33)13(34)9(40-19)3-4-31)20(39-7)41-17-11(30-22(26)27)14(35)10(29-21(24)25)15(36)16(17)37;1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h6-20,28,31,33-38H,3-5H2,1-2H3,(H4,24,25,29)(H4,26,27,30);3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t7-,8-,9-,10+,11-,12-,13-,14+,15-,16+,17+,18-,19-,20-,23+;11-,12+,14-/m01/s1
InChI key
KMOOCZWLFBSQCW-XFOLRDBHSA-N
sterility
0.1 μm filtered
product line
BioReagent
form
liquid
concentration
50 ×
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
protein synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
Quality Level
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This Item | 11074440001 | P4333 | P0781 |
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| mode of action cell wall synthesis | interferes, protein synthesis | interferes | mode of action cell wall synthesis | interferes, protein synthesis | interferes | mode of action cell wall synthesis | interferes, protein synthesis | interferes | mode of action cell wall synthesis | interferes, protein synthesis | interferes |
| product line BioReagent | product line - | product line BioReagent | product line BioReagent |
| Quality Level 300 | Quality Level 100 | Quality Level 300 | Quality Level 300 |
| form liquid | form lyophilized (clear, colorless solution after reconstitution) | form liquid | form liquid |
Application
Penicillin-Streptomycin has been used:
- as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) to maintain the Huh7 liver hepatoma cell line[1]
- as a supplement in Roswell park memorial institute-1640 (RPMI) medium to maintain mouse lymphoma YAC-1 cells[2]
- as a component in minimum essential medium Eagle to treat individual mouse spleens for the preparation of splenocytes[3]
- as a supplement in FMX-8 complete medium to culture Chinese hamster ovary cells[4]
Recommended for use in cell culture media at 20 ml/L.
Biochem/physiol Actions
Penicillins can prevent the synthesis of bacterial cell wall. This antibiotic can be used in the treatment of skin and urinary tract infections, upper and lower respiratory infections, and endocarditis.[5] Streptomycin can block Mycobacterium tuberculosis in vitro.[1] Streptomycin inhibits prokaryote protein synthesis[4] by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding.
General description
Other Notes
20ml,100ml
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
This product is formulated to contain 5,000 units penicillin and 5 mg streptomycin/mL solubilized in a proprietary citrate buffer.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Comprehensive Heterocyclic Chemistry III, 2, 173-237 (2008)
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Effect of Lactobacillus brevis KB290 on the cell-mediated cytotoxic activity of mouse splenocytes: a DNA microarray analysis
Fukui Y, et al.
The British Journal of Nutrition, 110(9), 1617-1629 (2013)
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Comprehensive Medicinal Chemistry II, 7, 629-652 (2007)
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What is the Department of Transportation shipping information for this product?
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What is the concentration of the P4458 Penicillin-Streptomycin solution? For example, is it a 50X or 100X?
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Product No. P4458 is designed to be added directly to media; you should add 20mL to 1L of medium. There is no intermediate dilution step. So the concentration 50X refers to the 50X dilution into media to the final working concentration.
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What is the storage temperature and the stability of the P4458 Penicillin-Streptomycin?
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Product No. P4458 (Penicillin-Streptomycin solution) should be stored in the freezer at -20 °C for long-term storage. It may be kept refrigerated at 2-8 °C for up to 40 days.
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What is the method of preparation for Product No. P4458 (Penicillin-Streptomycin); what solution is it made in?
1 answer-
Product No. P4458 is not simply penicillin and streptomycin dissolved in water; it is made in a proprietary buffer.
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