Immunoglobulin M (IgM) is a highly conserved antibody in vertebrates and shows early expression during the immune response. Peritoneal B cells secrete IgM and it exists as a pentamer. IgM plays a key role in engulfing the apoptotic cells. A reduction in the serum IgM levels leads to an increase in autoimmune response and a higher risk for infections. IgM displays polyreactive and autoreactive functionality. It plays a key role in tissue homeostasis by mediating the clearance of tissue-based molecules. The antibody pair provided in this kit recognizes mouse IgM.
For research use only. Not for use in diagnostic procedures. Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)