Merck
All Photos(4)

S1885

Sigma-Aldrich

Suberic acid bis(N-hydroxysuccinimide ester)

≥95%, powder

Synonym(s):
Disuccinimidyl suberate, Disuccinimidyl octanedioate, Disuccinimidyl suberate (DSS)
Empirical Formula (Hill Notation):
C16H20N2O8
CAS Number:
Molecular Weight:
368.34
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

assay

≥95%

form

powder

reaction suitability

reagent type: cross-linking reagent

solubility

chloroform: 50 mg/mL
DMF: soluble
aqueous buffer: slightly soluble (may require 5-10% organic solvent in coupling mixture.)

storage temp.

2-8°C

SMILES string

O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O

InChI

1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2

Inchi Key

ZWIBGKZDAWNIFC-UHFFFAOYSA-N

Related Categories

General description

Suberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.

Application

Suberic acid bis(N-hydroxysuccinimide ester) has been:
  • supplemented in pierce lysis buffer used for immunoprecipitation
  • used to conjugate the oligonucleotide standards to gelatin
  • used in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers

Packaging

500 mg in poly bottle
1, 5 g in poly bottle

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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