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DNA alkylation by ethylene oxide and some mono-substituted epoxides.
D Segerbäck
IARC scientific publications, (125)(125), 37-47 (1994-01-01)
Gregg A Mosley et al.
PDA journal of pharmaceutical science and technology, 58(2), 81-95 (2004-04-29)
Current approaches for validation of EtO sterilization cycles identified in ISO 11135 and EN 550 are scientifically deficient and result in full cycle times that are too short. This review article identifies the scientific flaws promulgated in the standards that
Otavio Machado de Almeida et al.
Acta cirurgica brasileira, 28(1), 66-71 (2013-01-23)
To compare three sterilization methods (autoclave, gamma irradiation and ethylene oxide) over non demineralized lyophilized bone allografts. Bone allografts were implanted on paravertebral muscles of 21 rats. After 30 days animals were sacrificed and grafts underwent comparative analysis regarding histomorphometric
Yifen Wen et al.
Colloids and surfaces. B, Biointerfaces, 133, 246-253 (2015-06-30)
Polysaccharide-based crosslinked nanogles (bionanogels) exhibiting multiple stimuli-responsive release of encapsulated therapeutics hold a great potential as tumor-targeting intracelluar durg delivery nanocarriers. Herein, we report the synthesis of monodisperse dual temperature/acidic pH-responsive bionanogels (DuR-BNGs) by aqueous crosslinking polymerization through temperature-induced self-association
Emad B Basalious et al.
International journal of pharmaceutics, 493(1-2), 347-356 (2015-08-05)
Subarachnoid hemorrhage (SAH) is a major cause of death in patients suffering from stroke. Nimodipine (NM) is the only FDA-approved drug for treating SAH-induced vasospasm. However, NM suffers from poor oral bioavailability (5-13%) due to its low aqueous solubility, extensive
Xiangjiang Liu et al.
Scientific reports, 5, 17167-17167 (2015-12-01)
Surface-enhanced Raman scattering (SERS) can significantly boost the inherently weak Raman scattering signal and provide detailed structural information and binding nature of the molecules on the surface. Despite the long history of this technology, SERS has yet to become a
V E Walker et al.
Mutation research, 233(1-2), 151-164 (1990-11-01)
The results of efforts to identify and quantify macromolecular adducts of ethylene oxide (ETO), to determine the source and significance of background levels of these adducts, and to generate molecular dosimetry data on these adducts are reviewed. A time-course study
Gigiena i sanitariia, (4)(4), 78-82 (2012-10-23)
The results of experimental studies on the development of gas chromatographic method for the determination of 1,3-butadiene and ethylene oxide in ambient air at the level of reference concentration with the use of sorption of the compounds studied from ambient
Zhengzan Zhang et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 92, 28-31 (2015-02-28)
The aim of this study was to load amorphous hydrophobic drug into ordered mesoporous silica (SBA-15) by supercritical carbon dioxide technology in order to improve the dissolution and bioavailability of the drug. Asarone was selected as a model drug due
Régis Coco et al.
International journal of pharmaceutics, 440(1), 3-12 (2012-07-24)
For inflammatory bowel disease (IBD) treatment, local delivery of molecules loaded in nanoparticles to the inflamed colon could be a promising strategy. The aim of this study was to investigate how drug-loaded polymeric nanoparticles target the site of inflammation and
Christian Gebauer et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(10), 2094-2107 (2014-05-23)
The potential of platinum catalysts supported on pure, nitrogen-, or carbon-doped titania for application in the oxygen reduction reaction (ORR), as a cathode catalyst in polymer electrolyte membrane fuel cells, is investigated. The oxide supports are synthesized by using a
J Luong et al.
Journal of chromatography. A, 1261, 136-141 (2012-07-20)
A portable, fast gas chromatographic method for the direct measurement of part-per-billion level of ethylene oxide in medical work place atmospheres is introduced. Ethylene oxide is a chemical of significance in life science for its critical role as a highly
Rita Cortesi et al.
International journal of pharmaceutics, 492(1-2), 291-300 (2015-07-19)
The aliphatic phosphine PTA (1,3,5-triaza-7-phosphaadamantane) is a promising ligand for metal complexes designed and developed as innovative inorganic drugs. In the present paper, an N-alkylated derivative of PTA, (PTAC16H33)X (X=I, C1, or X=PF6, C2) and its platinum coordination complex cis-[PtCl2(PTAC16H33)2](PF6)2
Ada Kolman et al.
Mutation research, 512(2-3), 173-194 (2002-12-05)
Ethylene oxide (EtO), propylene oxide (PO) and epichlorohydrin (ECH) are important industrial chemicals widely used as intermediates for various synthetic products. EtO and PO are also environmental pollutants. In this review we summarize data published during the period 1990-2001 concerning
Hui Jiang et al.
Analytica chimica acta, 888, 85-93 (2015-09-01)
The present work reports preparation of ordered mesoporous carbon (OMC) film supported on a graphite fiber as a new type of solid-phase microextraction (SPME) fiber for determination of benzene series from aqueous media. The strategy for the supported OMC film
S Ferraris et al.
Biomedical materials (Bristol, England), 7(5), 054102-054102 (2012-09-14)
Grafting of the biomaterial surfaces with biomolecules is nowadays a challenging research field for prosthetic and bone tissue engineering applications. On the other hand, very few research works investigate the effect of the sterilization processes on the properties of functionalized
Faisal I Khan et al.
Journal of hazardous materials, 108(3), 147-159 (2004-05-04)
This paper discusses a methodology for the design of an optimum inspection and maintenance program. The methodology, called risk-based maintenance (RBM) is based on integrating a reliability approach and a risk assessment strategy to obtain an optimum maintenance schedule. First
ortho?Carborane?Modified N?Substituted Deoxynojirimycin.
Hoogendoorn S
European Journal of Organic Chemistry, 2015(20), 4437-4446 (2015)
Rafael Queiroz de Souza et al.
Revista da Escola de Enfermagem da U S P, 47(2), 494-499 (2013-06-08)
Do materials sterilized using gamma rays become toxic when re-sterilized in ethylene oxide? This question guided the objective of this study, which was to investigate the potential cytotoxic effect of PVC sterilized by gamma radiation and re-sterilized with EO by
Sandra Ritz et al.
Biomacromolecules, 16(4), 1311-1321 (2015-03-21)
Understanding nanoparticle-protein interactions is a crucial issue in the development of targeted nanomaterial delivery. Besides unraveling the composition of the nanoparticle's protein coronas, distinct proteins thereof could control nanoparticle uptake into specific cell types. Here we differentially analyzed the protein
R J Preston
Critical reviews in toxicology, 29(3), 263-282 (1999-06-24)
Cytogenetic assays are an integral component of the battery of short-term assays that are used for the hazard identification component of a cancer risk assessment. The protocol for the conduct of such assays for maximal sensitivity for detecting clastogenicity has
Sandra Ullm et al.
Biomaterials, 35(37), 9755-9766 (2014-09-10)
Hydrogels prepared from gelatin and lysine diisocyanate ethyl ester provide tailorable elastic properties and degradation behavior. Their interaction with human aortic endothelial cells (HAEC) as well as human macrophages (Mɸ) and granulocytes (Gɸ) were explored. The experiments revealed a good
Ratiba Irinislimane et al.
Applied spectroscopy, 66(12), 1420-1425 (2012-12-13)
Commercial sunflower oil was epoxidized at the laboratory-scale. The epoxidized sunflower oil (ESFO) was modified following the acrylation reaction. Modification was carried out simultaneously using acrylic acid (AA) and triethylamine (TEA). To optimize the reaction conditions, the effects of four
Forrest S Gittleson et al.
ACS nano, 9(10), 10005-10017 (2015-09-08)
Fully integrated transparent devices require versatile architectures for energy storage, yet typical battery electrodes are thick (20-100 μm) and composed of optically absorbent materials. Reducing the length scale of active materials, assembling them with a controllable method and minimizing electrode
Tomoki Ogoshi et al.
Journal of the American Chemical Society, 134(49), 20146-20150 (2012-11-21)
A new water-soluble thermoresponsive pillar[6]arene with triethylene oxide groups was synthesized. The pillar[6]arene showed lower critical solution temperature behavior in aqueous solution. Its clouding point was photoreversibly switched based on a photoresponsive host-guest system. The trans form of an azobenzene
Christopher J Whiteoak et al.
Inorganic chemistry, 51(20), 10639-10649 (2012-09-26)
Iron(III) amino triphenolate complexes with different substituents in the ortho-position of the phenolate moiety (R = H, Me, tBu, or Ph) have been synthesized by the reaction of iron(III) chloride and the sodium salt (Na(3)L(R)) of the requisite ligand. The
Minoru Yoshimoto et al.
Journal of oleo science, 62(1), 45-50 (2013-01-30)
Physical properties (chemical adsorption rate, viscoelasticity, thickness, and conformation) for self-assembled monolayers (SAMs) of mercapto oligo (ethylene oxide) methyl ethers on gold were determined by quartz crystal microbalance (QCM). The values of thickness, shear viscosity and elastic shear modulus of
Immunochemical and GC/MS analysis of protein adducts: dosimetry studies with ethylene oxide.
D W Britton et al.
Progress in clinical and biological research, 372, 99-106 (1991-01-01)
Berthold Moser
Journal of occupational and environmental hygiene, 10(5), D62-D62 (2013-03-15)
Stephen Blackman et al.
Forensic science international. Genetics, 17, 137-148 (2015-05-20)
DNA profiling through the analysis of STRs remains one of the most widely used tools in human identification across the world. Current laboratory STR analysis is slow, costly and requires expert users and interpretation which can lead to instances of
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