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Christoph Matti et al.
Frontiers in immunology, 11, 720-720 (2020-05-12)
Chemokines are essential for guiding cell migration. Atypical chemokine receptors (ACKRs) contribute to the cell migration process by binding, internalizing and degrading local chemokines, which enables the formation of confined gradients. ACKRs are heptahelical membrane spanning molecules structurally related to
Po-Yuan Lin et al.
Biosensors, 2(4), 377-387 (2012-01-01)
Although still commonly used in clinical practice to screen and diagnose prostate cancer, there are numerous weaknesses of prostate-specific antigen (PSA) testing, including lack of specificity and the inability to distinguish between aggressive and indolent cancers. A promising prostate cancer
Mariane H Schleimann et al.
EBioMedicine, 45, 328-340 (2019-07-14)
TLR9 agonists are being developed as immunotherapy against malignancies and infections. TLR9 is primarily expressed in B cells and plasmacytoid dendritic cells (pDCs). TLR9 signalling may be critically important for B cell activity in lymph nodes but little is known
Christoph T A Meiringer et al.
Methods (San Diego, Calif.), 40(2), 171-176 (2006-10-03)
A protein's function depends on its localization to the right cellular compartment. A number of proteins require lipidation to associate with membranes. Protein palmitoylation is a reversible lipid modification and has been shown to mediate both membrane localization and control
E P Brass
Chemico-biological interactions, 90(3), 203-214 (1994-03-01)
Coenzyme A (CoASH) has a clearly defined role as a cofactor for a number of oxidative and biosynthetic reactions in intermediary metabolism. Formation of acyl-CoA thioesters from organic carboxylic acids activates the acid for further biotransformation reactions and facilitates enzyme
Signalling functions of coenzyme A and its derivatives in mammalian cells
Davaapil H, et al.
Biochemical Society Transactions, 42(4), 1056-1062 (2014)
Biosynthesis of pantothenic acid and coenzyme A
Ecosal plus, 2(2) (2007)
Benjamin J Des Soye et al.
Cell chemical biology, 26(12), 1743-1754 (2019-11-11)
The site-specific incorporation of non-canonical amino acids (ncAAs) into proteins via amber suppression provides access to novel protein properties, structures, and functions. Historically, poor protein expression yields resulting from release factor 1 (RF1) competition has limited this technology. To address
Dominique Pessayre et al.
Drug metabolism reviews, 44(1), 34-87 (2011-09-07)
A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events cause mitochondrial membrane disruption. Genetic or acquired factors predispose to metabolite-mediated hepatitis by increasing the
Chenming Ni et al.
Cancer letters, 498, 19-30 (2020-11-06)
The acyl-CoA thioesterase (ACOT) family catalyses the hydrolysis of acyl-CoA thioesters to their corresponding non-esterified fatty acid and coenzyme A (CoA). Increasing evidence suggests that cancer cells generally have altered lipid metabolism in different aspects. However, the roles of the
Mary C Hunt et al.
The Journal of biological chemistry, 277(2), 1128-1138 (2001-10-24)
Peroxisomes function in beta-oxidation of very long and long-chain fatty acids, dicarboxylic fatty acids, bile acid intermediates, prostaglandins, leukotrienes, thromboxanes, pristanic acid, and xenobiotic carboxylic acids. These lipids are mainly chain-shortened for excretion as the carboxylic acids or transported to
João Leandro et al.
Human molecular genetics, 29(7), 1168-1179 (2020-03-12)
Glutaric aciduria type 1 (GA1) is an inborn error of lysine degradation characterized by a specific encephalopathy that is caused by toxic accumulation of lysine degradation intermediates. Substrate reduction through inhibition of DHTKD1, an enzyme upstream of the defective glutaryl-CoA
Christoph Matti et al.
Journal of leukocyte biology, 107(6), 1137-1154 (2020-06-14)
The chemokine CCL20 is broadly produced by endothelial cells in the liver, the lung, in lymph nodes and mucosal lymphoid tissues, and recruits CCR6 expressing leukocytes, particularly dendritic cells, mature B cells, and subpopulations of T cells. How CCL20 is
David F Fischer et al.
Methods in molecular biology (Clifton, N.J.), 289, 303-314 (2004-10-27)
Protocols to study the regulation of a conserved multigene family (SPRR genes) during calcium-induced differentiation of cultured normal human keratinocytes (NHKs) are provided. Transfection of promoter-reporter (CAT or luciferase) constructs, combined with promoter truncation, can be used to study the
TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation.
Huh, et al.
Cell Metabolism, 32, 1012-1027 (2021)
Ahmed Sadik et al.
Cell, 182(5), 1252-1270 (2020-08-21)
Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation of AHR activity and its upstream enzymes across human cancers. A
Beate I Escher et al.
Environmental health perspectives, 128(7), 77007-77007 (2020-07-24)
High-throughput screening of chemicals with in vitro reporter gene assays in Tox21 has produced a large database on cytotoxicity and specific modes of action. However, the validity of some of the reported activities is questionable due to the "cytotoxicity burst,"
Grant A Mitchell et al.
Molecular genetics and metabolism, 94(1), 4-15 (2008-03-14)
Coenzyme A (CoA) sequestration, toxicity or redistribution (CASTOR) is predicted to occur in many hereditary and acquired conditions in which the degradation of organic acyl esters of CoA is impaired. The resulting accumulation of CoA esters and reduction of acetyl-CoA
Jasmine M Hershewe et al.
Nature communications, 12(1), 2363-2363 (2021-04-24)
Cell-free gene expression (CFE) systems from crude cellular extracts have attracted much attention for biomanufacturing and synthetic biology. However, activating membrane-dependent functionality of cell-derived vesicles in bacterial CFE systems has been limited. Here, we address this limitation by characterizing native
D C Rule et al.
Journal of animal science, 67(2), 364-373 (1989-02-01)
To compare genetic differences in glycerolipid biosynthesis, rates were determined in s.c. adipose tissue of lean and obese pigs at 28, 60 and 110 d of age. To compare depot-specific differences, glycerolipid biosynthetic rates were determined in outer s.c., middle
Analysis of gene promoter regulation by tumor suppressor genes.
Kumaravel Somasundaram et al.
Methods in molecular biology (Clifton, N.J.), 223, 101-116 (2003-06-05)
Melinda A Engevik et al.
Cellular and molecular gastroenterology and hepatology, 11(1), 221-248 (2020-08-17)
The human gut microbiota can regulate production of serotonin (5-hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms underlying microbial-induced serotonin signaling are not well understood. Adult germ-free mice were treated with sterile media, live Bifidobacterium dentium, heat-killed B dentium, or
Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.
Houston, et al.
PLoS Biology, 18, e3000981-e3000981 (2021)
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