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Poly(ethylene glycol) (PEG) and Synthetic PEG Derivatives for Tissue Engineering and Cell Delivery
Highlighting new synthetic modifications of PEG to improve the mechanical properties and degradation of resulting hydrogels in tissue engineering applications.
Smart Oligonucleotide Delivery by Multifunctional Block Copolymers
Kanjiro Miyata (The University of Tokyo, Japan) provides insights on the rational design of polymeric materials for “smart” oligonucleotide delivery.
Use of Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Bioimaging
Our highly fluorescent iron oxide incorporated conjugated polymer nanoparticles (CPNs) have an iron oxide and semiconductor light emitting polymer core, encapsulated within a biocompatible surfactant. The multi-modal particles can be used in both fluorescence and magnetic resonance imaging. Learn more
Chitosan-based Biomaterials
Chitin, a natural polysaccharide, is the second most abundant natural biopolymer in the world, after cellulose.
RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering
Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.
Electrospun Nanofibers for Drug Delivery Systems
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials
Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the
Tools for PEGylation
Polyethylene glycol (PEG) reagents offer numerous favorable characteristics, including high water solubility, high mobility in solution, lack of toxicity and immunogenicity, and ready clearance from the body.
Polyelectrolyte Multilayer Films and Membrane Functionalization
We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.
Fluorescent Microparticles and Nanobeads
Fluorescently labeled microparticles are useful as standards in flow cytometry, confocal laser scanning microscopy, and with light scattering instruments..
Reversible Addition Fragmentation Chain Transfer (RAFT) Polymerization
RAFT (Reversible Addition Fragmentation chain Transfer) polymerization is a reversible deactivation radical polymerization (RDRP) and one of the more versatile methods for providing living characteristics to radical polymerization.
Designing Temperature and pH Sensitive NIPAM Based Polymers
Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.
Halloysite Nanotubes Applications in Nanomaterials Research
Halloysite Nanotubes in Nanomaterials Research. Halloysite, a naturally occurring aluminosilicate nanotube, has been undeservedly forgotten.
Biodegradable Aliphatic Polyesters for Drug Delivery
Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.
Functional Biomaterials Synthesized by Double-Head Polymerization Agents
Over the past two decades, the rapid advance of controlled living polymerization (CLP) techniques.
Poly(2-Oxazoline)s: The Versatile Polymer Platform for Biomedicine
The introduction of polymers into the biomedical field has opened new avenues in tissue engineering, implant design, biosensing, and drug delivery.
Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation
Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.
Flash NanoPrecipitation (FNP) – Principles and Applications in Medical Imaging and Drug Delivery
Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.
Protein- and Peptide- Polymer Conjugates by RAFT Polymerization
The modification of biomacromolecules, such as peptides and proteins, through the attachment of synthetic polymers has led to a new family of highly advanced biomaterials with enhanced properties.
Polydiacetylene Nanotubes (PDNTs): Nanotubes Based On Lipid Diacetylene Materials
Polydiacetylene nanotubes (PDNTs) are self-assembled diacetylene nanotubes comprised of cross-linked, conjugated double and triple bonds.
Quantum Dots
Quantum dots are tiny particles or nanocrystals of a semiconducting material with diameters in the range of 2-10 nanometers.
Gold Nanoparticles: Properties and Applications
Gold (Au) nanoparticles have tunable optical and electronic properties and are used in a number of applications including photovoltaics, sensors, drug delivery & catalysis.
Functional RAFT Polymers for Biomedical Applications
Reversible addition–fragmentation chain transfer (RAFT) polymerization is rapidly moving to the forefront in construction of drug and gene delivery vehicles.
Silicon Carbide: The Return of an Old Friend
In recent years silicon carbide, SiC, has re-emerged as a vital technological material that is crucial in many materials and engineering applications.
Rational Design of ECMs Toward Cancer Immunotherapy
Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.
Delivery of Nucleic Acids Using Polymers
This review will focus on the sub-sector of drug delivery concerning the delivery of nucleic acids, with a particular focus on poly(ethyleneimine).
Applications of Y-Shape Peg Derivatives for Drug Delivery
The immune system protects the body from disease by resisting the invasion of foreign molecules into its cells, for example peptides and proteins are hydrolyzed by proteolytic enzymes; nucleic acids are hydrolyzed by nucleases; and most small molecules are eliminated
Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting
Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.
Smart Nanofiber Meshes as a Local Drug Delivery Platform
Professor Mitsuhiro Ebara provides insights on several types of smart nanofiber mesh systems that have been explored for different drug delivery purposes.
Synthesis and Biomedical Applications of Polyamino Acids
Polyamino acids are able to adopt ordered conformations, such as α-helices and β-sheets, through cooperative hydrogen bonding. These conformations impart polyamino acids with various unique properties and functions in biological environments.
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