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Protein expression

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Signal Peptide Optimization: Effect On Recombinant Monoclonal IgG Productivity, Product Quality And Antigen-Binding Affinity
A signal peptide is a 5-30 amino acid (aa) peptide present at the N-terminus of secretory proteins.
Platelet Derived Growth Factors (PDGF)
Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.
Cell Lines for Recombinant Protein Expression
Eukaryotic cell lines aid in complex post-translational modifications and folding of recombinant proteins. Find suitable recombinant protein production cell lines.
Our company offers many products related to EGFR for your research needs.
Glutamate/GABA Synthesis and Metabolism
Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. The neurotransmitter glutamate can be synthesized from glutamine by the action of
Protein Expression Systems
The development of genetic engineering and cloning has opened many possibilities of expression and isolation of heterologous proteins for research purposes. Considerable advances in technology have enabled expression and isolation of recombinant proteins in large scale.
Inhibition of Protein Synthesis by Antibiotics
Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial
Phospholipase A2
Phospholipase A2 (PLA2) designates a class of enzymes that hydrolyze the sn-2 ester of glycerophospholipids to produce a fatty acid and a lysophospholipid. It has become clear that some of these enzymes liberate arachidonic acid in mammalian cells for the
Dopamine, Norepinephrine and Ephinephrine Synthesis
Dopamine-β-hydroxylase is located inside amine storage vesicles of norepinephrine neurons. Dopamine is actively transported from the cytoplasm into the vesicles. As the enzyme is a copper containing protein, its activity can be inhibited by copper chelating agents, such as diethyldithiocarbamate
An ECM Mimetic Library for Engineering Surfaces to Direct Cell Surface Receptor Binding Specificity and Signaling
The extracellular (ECM) microenvironment, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions. For this reason, engineering the ECM microenvironment provides
Phase I Drug Metabolism
Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs
ATP Synthase
Learn about ATP synthase with our molecular machine video animation showing this mechanism that provides energy to cells. Our animation is provided in partnership with Dr Nicholson and the IUBMB.
The Role of Liver Transporters in Drug-Drug Interactions
Oral drug delivery involves dissolution in the small intestine and absorption across the enterocyte barrier into the portal vein followed by subsequent delivery through the liver into the systemic circulation.
Cloning & Expression Vectors
Expression Vectors for Bacterial, Mammalian and Insect Cell Systems. Featured are a variety of tags, promoters and elements for secretion, transient, stable and bicistronic expression.
p53: DNA Damage Response and Cancer
p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.
3xFLAG® System Expression Vectors for Ultra-Sensitive Detection of Recombinant Proteins
The 3xFLAG system is an improvement upon the original system by fusing 3 tandem FLAG® epitopes for a total of 22 amino acids. Detection of fusion proteins containing 3xFLAG is enhanced up to 200 times more than any other system.
Hypoxia Detection Assays
Hypoxia detection assays to measure oxygen levels in both live and fixed cells and tissues.
Galanin Receptors
We offer many products related to galanin receptors for your research needs.
Serotonin Receptors
We offer many products related to serotonin receptors for your research needs.
Directed Evolution
An overview of directed evolution and the methods for generating proteins with optimized or entirely new functions.
Overview of G Protein-coupled Receptors (GPCRs)
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Tag Removal Proteases for Recombinant Protein Purification
Proteases for biotinylated tag removal for protein purification workflows with related reagents and technical resources.
ABC Transporters and Cancer Drug Resistance
We presents an article on ABC Transporters and Cancer Drug Resistance
P2 Receptors: P2Y G-Protein Family Overview
We offer many products related to P2Y G-protein family receptors for your research needs.
Melatonin Receptors
We offer many products related to melatonin receptors for your research needs.
Sigma Receptors
Sigma receptors may constitute favorable targets for drug design in conditions such as psychiatric and movement disorders, amnesia, depression, cancer, inflammation and cocaine addiction.
Lipid-induced Insulin Resistance
Lipid Induced Insulin Resistance
Glutamate Receptors (G Protein Family)
Sigma-Aldrich offers many products related to G-protein family glutamate receptors for your research needs.
c-Src kinase (Csk)
The C-terminal c-Src kinase (Csk) is a 50-kDa cytosolic tyrosine kinase expressed in all examined cell types
Adenosine Receptors
We offers many products related to adenosine receptors for your research needs.
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