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Two Distinct Sample Prep Approaches to Overcome Matrix Effect in LC/MS of Serum or Plasma Samples
This article highlights the impact that sample matrix effects can have on LC/MS response and discusses two novel approaches to reduce it.
Supel™-Select Polymeric SPE
Supel-Select HLB SPE - a hydrophilic modified styrene based polymer developed for the solid phase extraction of a broad range of compounds from aqueous samples.
Solid Phase Extraction: Ion Exchange Methodology
SPE retention mechanism in this case is based on the electrostatic attraction of charged functional groups of the analyte(s) to oppositely charged functional groups on the sorbent.
Replace Classical Liquid-Liquid Extractions with EXtrelut® NT
Simplify your liquid-liquid extractions with our emulsion-free supported-liquid extraction (SLE) single step solution.
Vitamin D epi-Metabolites Separated with HybridSPE-Phospholipid
This Sigma-Aldrich article continues to detail new methodology for the analysis of Vitamin D metabolites using HybridSPE-Phospholipid technology.
QuEChERS Cleanup and Analysis of Veterinary Drugs in Milk by LC/MS/MS
Use QuEChERS methods to analyze samples of milk for veterinary drugs.
LC-MS Analysis of Serum for a Wide Analyte Range Using a Novel HLB SPE Phase
Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.
LC-MS Analysis of PFAS Compounds in EPA Method 533 using Supelclean™ ENVI-WAX™ SPE
Learn how method EPA 533 is used for sample collection and preparation, featuring Supelclean™ ENVI-WAX™ SPE cartridges for LC-MS analysis on an Ascentis® Express PFAS HPLC Column.
The Extraction of Amphetamine and Related Drugs using Molecularly Imprinted Polymer SPE
The Extraction of Amphetamine and Related Drugs using Molecularly Imprinted Polymer SPE
LC-MS Analysis of Warfarin™ in Plasma Samples
LC-MS analysis of Warfarin demonstrates its potential in clinical laboratories for accurate plasma measurements.
Steroid Hormone Analysis with Supel™ Swift HLB DPX
Accurate steroid analysis in blood serum using Supel™ Swift HLB DPX Tips; UTAK and NIST standards.
Workflow for Pesticide Analysis in Cannabis
Complete workflow for cannabis flower pesticide testing using LC-MS/MS and GC-MS/MS ensures product safety.
Simplified LC-MS/MS for Herbicides in Cereals
Glyphosate analysis: LC-MS/MS method with Supel™ Carbon LC U/HPLC column for stability and retention.
Solid Phase Extraction (SPE) Overview
Solid phase extraction method extracts, partitions, and adsorbs components from liquid samples onto stationary phase resin.
Supel™ Swift HLB SPE Cartridges
Supel™ Swift HLB SPE enhances solid phase extraction efficiency with faster flow rates and minimal signal interference.
Analysis of Pesticide Residues in Pistachios Using QuEChERS Extraction and Cleanup with Supel™ QuE Z-Sep+
Pistachios 45% fat complicates pesticide analysis. But Z-Sep+ sorbent cleanup after QuEChERS extraction can reduce background for reliable results.
Solid Phase Extraction: Ion Exchange Methodology
SPE retention mechanism in this case is based on the electrostatic attraction of charged functional groups of the analyte(s) to oppositely charged functional groups on the sorbent.
HybridSPE-Phospholipid Technology
This Sigma-Aldrich article discusses how the HybridSPE-Phospholipid Technology works and how the phospholipids are removed.
Impact of Mobile Phase Additives on LC-MS Sensitivity, Demonstrated using Spice Cannabinoids
This study demonstrates the impact of various mobile phase modifiers on the separation; formate modifiers outperform acetate in terms of MS signals (or sensitivity) and chromatographic resolution.
Quick, Sensitive LC/MS/MS Analysis of Aflatoxins in Cannabis
Analyte recovery values from spiked cannabis extracts ranged from 102 to 127% with RSD below 12% for 3 replicates. Excellent recovery values were even observed for Aflatoxins B2 and G2 which were spiked at a low level of 6.1 ppb.
LC/MS/MS Method for Determination of Glyphosate, AMPA, and Glufosinate in Cereals
Glyphosate and related compounds are measured in oatmeal and infant cereal using ion-exchange polymer-based particles for HPLC and SPE. Low level detection was obtained.
Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum
Novel sample prep technique coupled with the unique selectivity of the Ascentis Express F5 column enables a fast and simplified bioanalytical method for associated vitamin D metabolites.
Ion Exchange Methodology
Ion Exchange Methodology in Sold Phase Extraction, Counter Ion Selectivity & Ion Exchange and the basic steps.
Ion-Suppression & Phospholipid Contamination
We are presenting an article focusing on ion-suppression and phospholipid contamination and some of their major causes and difficulties.
Solid Phase Extraction: Reversed-Phase Methodology
Reversed-phase interaction will retain most molecules with hydrophobic character; it is very useful for extracting analytes that are very diverse in structure within the same sample.
Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum
Using HybridSPE-Phospholipid, Ascentis Express, and Other LC-MS Workflow Components
Sample Cleanliness Using BioSPME
Learn about Supel™ BioSPME C18 96-pin tool to prepare a clean sample with minimal matrix effects for an LC-MS/MS analysis from human plasma and its comparison with acetonitrile-based precipitation.
Solid Phase Extraction for Aflatoxin Analysis
Supel Tox AflaZea SPE improves analyte recovery with less sample volume, while HPLC confirms effective elimination of interferences.
Pesticide Residue Analysis in Ginger Powder with QuEChERS
2-layer SPE cartridge efficiently reduces background for ginger contaminant analysis.
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