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Valerio Pazienza et al.
Aging, 6(1), 35-47 (2014-01-30)
Non-alcoholic-fatty-liver-disease (NAFLD) encompasses conditions associated to fat deposition in the liver, which are generally deteriorated during the aging process. MacroH2A1, a variant of histone H2A, is a key transcriptional regulator involved in tumorigenic processes and cell senescence, and featuring two
Xiaobing Yang et al.
Bioresource technology, 193, 557-562 (2015-07-15)
Microbial lipids produced by oleaginous yeasts serve as promising alternatives to traditional oils and fats for the production of biodiesel and oleochemicals. To improve its techno-economics, it is pivotal to use wastes and produce high quality lipids of special fatty
Mohamad Navab et al.
Journal of lipid research, 56(4), 871-887 (2015-02-04)
We previously reported that i) a Western diet increased levels of unsaturated lysophosphatidic acid (LPA) in small intestine and plasma of LDL receptor null (LDLR(-/-)) mice, and ii) supplementing standard mouse chow with unsaturated (but not saturated) LPA produced dyslipidemia
Old study sheds new light on the fatty acids and cardiovascular health debate.
Philip C Calder
BMJ (Clinical research ed.), 346, f493-f493 (2013-02-07)
Shimeng Guo et al.
PloS one, 10(10), e0141303-e0141303 (2015-10-28)
Type 2 Diabetes Mellitus with insulin resistance, pancreatic β cell dysfunction, and hepatic glucose overproduction is increasing in epidemic proportions worldwide. G protein-coupled receptor 40 (GPR40), a clinically proven anti-diabetic drug target, is mainly expressed in pancreatic β cells and
Oswald Quehenberger et al.
Journal of lipid research, 51(11), 3299-3305 (2010-07-31)
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test
Monika A Zielińska-Pisklak et al.
Journal of pharmaceutical and biomedical analysis, 102, 54-63 (2014-09-23)
The antioxidant activity of the crude extract (60% ethanol) from the leaves of Desmodium adscendens (Sw.) DC. (Fabaceae) was observed in DPPH, xanthine/xanthine oxidase, lipid peroxydation and neutrophils burst tests. Further activity-guided fractionation on C18 column (water, 20% methanol, 50%
Christina N Robitaille et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 126-135 (2014-10-18)
Several pesticides suspected or known to have endocrine disrupting effects were screened for pro- or antiandrogenic properties by determining their effects on proliferation, prostatic-specific antigen (PSA) secretion and androgen receptor (AR) expression, and AR phosphorylation in androgen-dependent LNCaP human prostate
Christine Podrini et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 1676-1687 (2014-12-21)
The importance of epigenetic changes in the development of hepatic steatosis is largely unknown. The histone variant macroH2A1 under alternative splicing gives rise to macroH2A1.1 and macroH2A1.2. In this study, we show that the macroH2A1 isoforms play an important role
María Isabel Giacopini de Z et al.
Investigacion clinica, 54(2), 171-179 (2013-08-21)
We analyzed in 31 subjects, regular guests of the University food service of the Central University of Venezuela (UCVFS), in Caracas, the effects of replacing sunflower oil, commonly used in the preparation of meals, by a mix of sunflower oil
Richa Rathod et al.
Brain & development, 36(10), 853-863 (2014-01-15)
The consequences of wide spread vegetarianism due to low vitamin B12 on brain development and functioning is gaining importance. However, there are no studies which have evaluated exclusively vitamin B12 supplementation during pregnancy on brain growth. A series of our
Anastasia Tkacheva et al.
ChemSusChem, 8(16), 2670-2680 (2015-07-23)
Amidation of renewable feedstocks, such as fatty acids, esters, and Chlorella alga based biodiesel, was demonstrated with zeolites and mesoporous materials as catalysts and ethanolamine, alaninol, and leucinol. The last two can be derived from amino acids present in alga.
Paul A Turner et al.
Tissue engineering. Part A, 21(11-12), 1837-1847 (2015-03-18)
To improve treatment of obesity, a contributing factor to multiple systemic and metabolic diseases, a better understanding of metabolic state and environmental stress at the cellular level is essential. This work presents development of a three-dimensional (3D) in vitro model
Imen Lassoued et al.
Journal of proteomics, 128, 458-468 (2015-05-17)
Thornback ray muscle hydrolysates (TRMHs) prepared by treatment with proteases from Bacillus subtilis A26 (TRMH-A26), Raja clavata crude alkaline protease extract (TRMH-Crude), Alcalase (TRMH-Alcalase) and Neutrase (TRMH-Neutrase) were elaborated and their antioxidant properties and angiotensin I-converting enzyme (ACE) inhibitory activities
Nathalie Nicod et al.
The Journal of nutritional biochemistry, 26(2), 165-172 (2014-12-04)
High-density lipoproteins (HDLs) are atheroprotective because of their role in reverse cholesterol transport. The intestine is involved in this process because it synthesizes HDL, removes cholesterol from plasma and excretes it into the lumen. We investigated the role of selected
Wusigale et al.
Journal of agricultural and food chemistry, 68(1), 340-350 (2019-12-25)
Folic acid, a synthetic form of folate, is a water-soluble vitamin that is essential during periods of rapid cell division and growth. However, it decomposes upon ultraviolet irradiation to form inactive photoproducts. In this study, the protective effect and mechanisms
Saïd Gharby et al.
Natural product communications, 8(1), 25-28 (2013-03-12)
Deforestation is an important matter for the argan forest whose preservation necessitates planting trees. Macroscopic parameters are urgently needed to identify trees presenting good potential as oil producers. This study demonstrates that argan oil produced from kernels of apiculate fruit
Hiroyasu Iso et al.
Stroke, 33(8), 2086-2093 (2002-08-03)
The role of serum fatty acids as a risk factor for stroke and stroke subtypes is largely unknown. A prospective nested case-control study of Japanese 40 to 85 years of age was conducted through the use of frozen serum samples
Wan Mohd Nuzul Hakimi Salleh et al.
Natural product communications, 10(8), 1465-1468 (2015-10-06)
The essential oils of Cinnamomum griffithii and C. macrocarpum were analyzed by GC and GC-MS and evaluated for their antioxidant and anticholinesterase activities. The essential oils of leaf and bark of C. grffithii were characterized by the presence of 30
Karen Kleberg et al.
The Journal of physiology, 593(8), 2097-2109 (2015-02-03)
Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensing to food intake and the activation of brain circuits remain to be identified. In this
Margit M McGowan et al.
Breast cancer research and treatment, 138(1), 175-183 (2013-02-19)
Conjugated linoleic acid (CLA) is widely used as a "nutraceutical" for weight loss. CLA has anticancer effects in preclinical models, and we demonstrated in vitro that this can be attributed to the suppression of fatty acid (FA) synthesis. We tested
Brian T Steffen et al.
The British journal of nutrition, 110(9), 1664-1671 (2013-04-05)
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent risk factor for CVD and has been proposed as a marker of vascular inflammation. Polyunsaturated n-3 fatty acids (FA) and several n-6 FA are known to suppress inflammation and may influence Lp-PLA2 mass
Josefin Larsson et al.
Journal of natural products, 68(7), 985-991 (2005-07-26)
Recently various attempts have been made to increase the efficacy and precision of chemical libraries used in high-throughput screening (HTS) drug discovery approaches. One such approach is ChemGPS, which provides a defined chemical space for prescreening evaluation of chemical compound
Yardfon Tanongkankit et al.
Journal of food science and technology, 52(4), 2280-2287 (2015-04-02)
White cabbage outer leaves, which are usually discarded both during industrial processing and selling in a consumer market, have proven to be a good source of dietary fiber (DF) as well as antioxidants and can be effectively transformed into functional
Manish K Pandey et al.
BMC genetics, 15, 133-133 (2014-12-11)
Peanut is one of the major source for human consumption worldwide and its seed contain approximately 50% oil. Improvement of oil content and quality traits (high oleic and low linoleic acid) in peanut could be accelerated by exploiting linked markers
Guy H Johnson et al.
Journal of the Academy of Nutrition and Dietetics, 112(7), 1029-1041 (2012-08-15)
The majority of evidence suggests that n-6 polyunsaturated fatty acids, including linoleic acid (LA), reduce the risk of cardiovascular disease as reflected by current dietary recommendations. However, concern has been expressed that a high intake of dietary n-6 polyunsaturated fatty
V van Drongelen et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(12), 1515-1524 (2014-10-30)
Atopic dermatitis is an inflammatory skin disease that is characterized by a reduced skin barrier function, reduced filaggrin (FLG) expression as well as increased colonization by Staphylococcus aureus. This study focused on the possible involvement of FLG in epidermal colonization
Shohreh Nikoo et al.
Molecular human reproduction, 20(9), 905-918 (2014-06-19)
Retrograde flow of menstrual blood cells during menstruation is considered as the dominant theory for the development of endometriosis. Moreover, current evidence suggests that endometrial-derived stem cells are key players in the pathogenesis of endometriosis. In particular, endometrial stromal stem
Amit Kumar et al.
Nutrition & metabolism, 12, 8-8 (2015-03-19)
The hallmark of Type 2 diabetes (T2D) is hyperglycemia, although there are multiple other metabolic abnormalities that occur with T2D, including insulin resistance and dyslipidemia. To advance T2D prevention and develop targeted therapies for its treatment, a greater understanding of
Marianna Raczyk et al.
Journal of the American Oil Chemists' Society, 94(5), 701-711 (2017-05-10)
This study examined the thermo-oxidative degradation of stigmasterol fatty acids esters. Stigmasterol stearate, oleate, linoleate and linolenate were synthesized by chemical esterification and their purity evaluated by
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