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Ved Vati Singh et al.
Dalton transactions (Cambridge, England : 2003), 43(33), 12555-12563 (2014-07-10)
Nanoflowers and nanospheres of Pd4S have been prepared for the first time from a single source precursor complex, [PdCl2(PhS-CH2CH2CH2-NH2)] (), by its one pot thermolysis at 195 °C. In oleylamine, flower shaped nanoparticles of Pd4S were formed but in an
Li-Fen Chiang et al.
Journal of hazardous materials, 277, 84-92 (2014-02-22)
In this study, the microwave-assisted sol-gel method and chemical reduction were used to synthesize Cu-TiO2 nanorod composites for enhanced photocatalytic degradation of bisphenol A (BPA) in the presence of UV and visible lights. The electron microscopic images showed that the
Mohammed Sattar et al.
International journal of pharmaceutics, 493(1-2), 146-151 (2015-07-22)
Naratriptan (NAR) is currently used for the management of migraine as the hydrochloride salt (NAR.HCl) and is administered as an oral tablet. This work evaluates the feasibility of buccal delivery of NAR in order to ensure faster onset of action
Ryan J Schulze et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(51), 32443-32452 (2020-12-09)
Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-directed process of autophagy. An organelle-selective form of this process (macrolipophagy) results in the engulfment of LDs within double-membrane delimited structures (autophagosomes) before lysosomal fusion. Whether this is an exclusive autophagic
Valerio Pazienza et al.
Aging, 6(1), 35-47 (2014-01-30)
Non-alcoholic-fatty-liver-disease (NAFLD) encompasses conditions associated to fat deposition in the liver, which are generally deteriorated during the aging process. MacroH2A1, a variant of histone H2A, is a key transcriptional regulator involved in tumorigenic processes and cell senescence, and featuring two
Matthew D Greseth et al.
PLoS pathogens, 10(3), e1004021-e1004021 (2014-03-22)
The poxvirus life cycle, although physically autonomous from the host nucleus, is nevertheless dependent upon cellular functions. A requirement for de novo fatty acid biosynthesis was implied by our previous demonstration that cerulenin, a fatty acid synthase inhibitor, impaired vaccinia
Xiaobing Yang et al.
Bioresource technology, 193, 557-562 (2015-07-15)
Microbial lipids produced by oleaginous yeasts serve as promising alternatives to traditional oils and fats for the production of biodiesel and oleochemicals. To improve its techno-economics, it is pivotal to use wastes and produce high quality lipids of special fatty
Paola Mura et al.
International journal of pharmaceutics, 475(1-2), 306-314 (2014-09-10)
Transdermal administration of clonazepam, a poorly water-soluble benzodiazepine, is an interesting strategy for overcoming the drawbacks of its oral administration. With this aim, two nano-carrier formulations, based on ultra-deformable liposomes and microemulsions, have been developed to favour clonazepam transdermal delivery.
Wim Reybroeck et al.
PloS one, 9(5), e98266-e98266 (2014-05-24)
Two Pseudomonas strains, identified as closely related to Pseudomonas tolaasii, were isolated from milk of a farm with frequent false-positive Delvotest results for screening putative antibiotic residues in raw milk executed as part of the regulatory quality programme. Growth at
Mónica Estupiñán et al.
PloS one, 10(7), e0131462-e0131462 (2015-07-15)
As previously reported, P. aeruginosa genes PA2077 and PA2078 code for 10S-DOX (10S-Dioxygenase) and 7,10-DS (7,10-Diol Synthase) enzymes involved in long-chain fatty acid oxygenation through the recently described oleate-diol synthase pathway. Analysis of the amino acid sequence of both enzymes
Mohamad Navab et al.
Journal of lipid research, 56(4), 871-887 (2015-02-04)
We previously reported that i) a Western diet increased levels of unsaturated lysophosphatidic acid (LPA) in small intestine and plasma of LDL receptor null (LDLR(-/-)) mice, and ii) supplementing standard mouse chow with unsaturated (but not saturated) LPA produced dyslipidemia
Achyut Khire et al.
Drug delivery and translational research, 4(2), 105-115 (2015-03-20)
The first objective of the proposed research work includes comparative bioavailability and bioequivalence evaluation of oxybutynin transdermal patch with respect to different permeation enhancers. The second objective was to evaluate different in vitro methods along with synthetic membranes toward development
Jean-Philippe Lanoix et al.
Disease models & mechanisms, 8(6), 603-610 (2015-06-04)
Mice are the most commonly used species for non-clinical evaluations of drug efficacy against tuberculosis (TB). Unlike commonly used strains, C3HeB/FeJ mice develop caseous necrosis in the lung, which might alter the representation of drug efficacy in a way that
Oswald Quehenberger et al.
Journal of lipid research, 51(11), 3299-3305 (2010-07-31)
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test
Karen J Kieser et al.
PLoS pathogens, 11(6), e1005010-e1005010 (2015-06-27)
Cell growth and division are required for the progression of bacterial infections. Most rod-shaped bacteria grow by inserting new cell wall along their mid-section. However, mycobacteria, including the human pathogen Mycobacterium tuberculosis, produce new cell wall material at their poles.
Elisenda Alsina-Sanchis et al.
Molecular cancer research : MCR, 19(2), 288-300 (2020-11-04)
Oil is frequently used as a solvent to inject lipophilic substances into the peritoneum of laboratory animals. Although mineral oil causes chronic peritoneal inflammation, little is known whether other oils are better suited. We show that olive, peanut, corn, or
Marco Ruggiero et al.
Anticancer research, 34(7), 3569-3578 (2014-07-02)
Oleic Acid (OA) has been shown to have anticancer properties mediated by interaction with proteins such as α-lactalbumin and lactoferrins. Therefore, we synthesized complexes of OA and Gc protein-derived macrophage activating factor (GcMAF) that inhibits per se cancer cell proliferation
Juan A Ramos Guivar et al.
Talanta, 141, 307-314 (2015-05-13)
Magnetic nanoparticles have been applied in many areas of nanomedicine. Sensing platforms based on this type of nanoparticles have received attention due to the relative low cost and biocompatibility. Biosensor is the most widely investigated type of analytical device. This
Martin J Wolf et al.
Environmental science & technology, 53(3), 1139-1149 (2018-12-28)
Sea spray is the largest aerosol source on Earth. Bubble bursting mechanisms at the ocean surface create smaller film burst and larger jet drop particles. This study quantified the effects of particle chemistry on the depositional ice nucleation efficiency of
Jaydeep Patel et al.
Drug delivery, 21(6), 412-435 (2013-11-13)
The present investigation was aimed to develop self-nanoemulsifying tablets (SNETs) as novel nanosized solid oral dosage forms for Irbesartan (IRB). In the first part of the investigation, IRB-loaded self-nanoemulsifying drug delivery systems (SNEDDS) were developed using Capryol 90 - Cremophor
Yoshiyuki Mizushina et al.
Mini reviews in medicinal chemistry, 12(11), 1135-1143 (2012-08-11)
Telomerase is a ribonucleoprotein complex that elongates telomeric DNA and appears to play an important part in the cellular immortalization of cancers. In the screening of potent inhibitors of human telomerase, several inhibitors have been discovered from natural and chemical
Emma Lawless et al.
Pharmaceutical research, 32(5), 1817-1829 (2014-11-28)
Intestinal lymphatic transport of specific lipophilic drugs offers therapeutic advantages and maximises oral bioavailability. The aims of this study were; to compare intestinal lymphatic transport of a range of drugs and to investigate the influence of cyclosporine A on the
K B Cullberg et al.
Nutrition & diabetes, 4, e113-e113 (2014-03-26)
High levels of free fatty acids (FFA) have been suggested to be one of the underlying mechanisms for adipose tissue (AT) inflammation and dysfunction in obesity. Human AT produces several adipokines including monocyte chemoattractant protein-1 (MCP-1), which are involved in
Aparna Akella et al.
Indian journal of experimental biology, 52(7), 712-719 (2014-07-26)
Animal studies using oleic acid (OA) model to produce acute respiratory distress syndrome (ARDS) have been inconsistent. Therefore, the present study was undertaken to establish an acute model of ARDS in rats using OA and to characterize its effect on
Christine Podrini et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 1676-1687 (2014-12-21)
The importance of epigenetic changes in the development of hepatic steatosis is largely unknown. The histone variant macroH2A1 under alternative splicing gives rise to macroH2A1.1 and macroH2A1.2. In this study, we show that the macroH2A1 isoforms play an important role
Meshail Okla et al.
Lipids, 50(2), 111-120 (2014-12-24)
Adult humans have a substantial amount of inducible-brown (or beige) fat, which is associated with increased energy expenditure and reduced weight gain via thermogenesis. Despite the identification of key regulators of beige adipogenesis, impacts of dietary factors on adaptive thermogenesis
Possible mechanism of cytotoxicity of α-lactalbumin-oleic acid complexes.
O M Zherelova et al.
Doklady. Biochemistry and biophysics, 448, 46-48 (2013-03-13)
Mohammad Sajid Ali et al.
Iranian journal of pharmaceutical research : IJPR, 13(4), 1125-1140 (2015-01-15)
Benign prostatic hyperplasia (BPH)is the most common condition in aging men, associated with lower urinary tract symptoms. It is caused due to the augmented levels of the androgen dihydrotestosterone. Dutasteride, a 5α-Reductase inhibitor has been recommended for the treatment of
Romal K Jassar et al.
Pediatric pulmonology, 49(12), 1214-1222 (2014-02-07)
High flow nasal cannula (HFNC) improves ventilation by washing out nasopharyngeal dead space while delivering oxygen. Heliox (helium-oxygen gas mixture), a low-density gas mixture, decreases resistance to airflow, reduces the work of breathing, and facilitates distribution of inspired gas. Excessive
Anastasia Tkacheva et al.
ChemSusChem, 8(16), 2670-2680 (2015-07-23)
Amidation of renewable feedstocks, such as fatty acids, esters, and Chlorella alga based biodiesel, was demonstrated with zeolites and mesoporous materials as catalysts and ethanolamine, alaninol, and leucinol. The last two can be derived from amino acids present in alga.
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