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Katsuya Nagaoka et al.
Molecular and cellular biology, 35(7), 1068-1080 (2015-01-28)
Cells link environmental fluctuations, such as nutrition, to metabolic remodeling. Epigenetic factors are thought to be involved in such cellular processes, but the molecular basis remains unclear. Here we report that the lysine-specific demethylase 2 (LSD2) suppresses the flux and
Ryan E Feaver et al.
JCI insight, 1(20), e90954-e90954 (2016-12-13)
A barrier to drug development for nonalcoholic steatohepatitis (NASH) is the absence of translational preclinical human-relevant systems. An in vitro liver model was engineered to incorporate hepatic sinusoidal flow, transport, and lipotoxic stress risk factors (glucose, insulin, free fatty acids)
Atsushi Kambayashi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 236-243 (2014-01-28)
The objective of this research was to characterize the dissolution profile of a poorly soluble drug, diclofenac, from a commercially available multiple-unit enteric coated dosage form, Diclo-Puren® capsules, and to develop a predictive model for its oral pharmacokinetic profile. The
Hongseok Yun et al.
ACS nano, 8(12), 12323-12337 (2014-11-13)
We investigate the size- and composition-dependent ac magnetic permeability of superparamagnetic iron oxide nanocrystals for radio frequency (RF) applications. The nanocrystals are obtained through high-temperature decomposition synthesis, and their stoichiometry is determined by Mössbauer spectroscopy. Two sets of oxides are
Lior Ziserman et al.
Langmuir : the ACS journal of surfaces and colloids, 25(18), 10483-10489 (2009-07-04)
The rheology of wormlike micelles ("worms") formed by surfactants in water often follows nonmonotonic trends as functions of composition. For example, a study by Raghavan et al. (Langmuir 2002, 18, 3797) on mixtures of the anionic surfactant sodium oleate (NaOA)
Tapan Dave et al.
SLAS discovery : advancing life sciences R & D, 23(3), 274-282 (2017-11-15)
In the recent past, there has been a growing interest in developing nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) therapeutics. As a result, a need for in vitro cell models of human hepatic steatosis and high-throughput assays to
Craig van Rensburg et al.
PloS one, 14(6), e0217820-e0217820 (2019-06-07)
Drug resistant-tuberculosis is a growing burden on the South African health care budget. In response the National Department of Health implemented two important strategies in 2011; universal access to drug-sensitivity testing for rifampicin with Xpert MTB/RIF as the first-line diagnostic
Dong-Gyu Lee et al.
ACS nano, 8(5), 4510-4521 (2014-04-24)
This paper reports the findings of our efforts toward gaining a more complete understanding and utilization of galvanic replacement reactions involving manganese oxide with noble metals. It was revealed that the site of metal deposition is significantly affected by the
Prasuna Koshy et al.
The journal of physical chemistry. B, 115(37), 10817-10825 (2011-08-11)
Natural fatty acids such as sodium oleate form highly viscous supramolecular complexes with long-chain cationic surfactants through cooperative self-assembly. Here we report the rheological behavior of linear and branched wormlike micelles formed in mixtures of cetyltrimethylammonium bromide (CTAB) and sodium
Andrey G Malyutin et al.
ACS applied materials & interfaces, 7(22), 12089-12098 (2015-05-20)
Here we explore the formation of virus-like nanoparticles (VNPs) utilizing 22-24 nm iron oxide nanoparticles (NPs) as cores and proteins derived from viral capsids of brome mosaic virus (BMV) or hepatitis B virus (HBV) as shells. To accomplish that, hydrophobic
Xiaoyang Zhang et al.
Cellular and molecular gastroenterology and hepatology, 7(4), 763-781 (2019-03-05)
Obesity promotes the development of nonalcoholic fatty liver diseases (NAFLDs), yet not all obese patients develop NAFLD. The underlying causes for this discrepancy remain elusive. LPGAT1 is an acyltransferase that catalyzes the remodeling of phosphatidylglycerol (PG), a mitochondrial phospholipid implicated
Yun-Li Wu et al.
Journal of virology, 90(4), 1729-1740 (2015-12-08)
Hepatitis B virus (HBV) has been implicated as a potential trigger of hepatic steatosis although molecular mechanisms involved in the pathogenesis of HBV-associated hepatic steatosis still remain elusive. Our prior work has revealed that the expression level of liver fatty
Xuerui Yang et al.
Cell research, 19(4), 469-486 (2009-03-05)
The present study shows that double-stranded RNA-dependent protein kinase (PKR) regulates the protein expression level and phosphorylation of Bcl-2 and plays an anti-apoptotic role in human hepatocellular carcinoma cells (HepG2). In various types of cells, saturated free fatty acids (FFAs)
Yuhua Fu et al.
Cell research, 31(9), 965-979 (2021-07-10)
Degrading pathogenic proteins by degrader technologies such as PROTACs (proteolysis-targeting chimeras) provides promising therapeutic strategies, but selective degradation of non-protein pathogenic biomolecules has been challenging. Here, we demonstrate a novel strategy to degrade non-protein biomolecules by autophagy-tethering compounds (ATTECs), using
Kazuhiro Totoribe et al.
The International journal of artificial organs, 37(2), 99-108 (2014-03-13)
The purpose of this study is to investigate the influence of changes in the human serum albumin (HSA) and free fatty acid (FFA) on alteration of the binding abilities of sites I and II after the operation of an artificial
Shahar Azar et al.
Molecular metabolism, 42, 101087-101087 (2020-09-29)
The endocannabinoid (eCB) system is increasingly recognized as being crucially important in obesity-related hepatic steatosis. By activating the hepatic cannabinoid-1 receptor (CB1R), eCBs modulate lipogenesis and fatty acid oxidation. However, the underlying molecular mechanisms are largely unknown. We combined unbiased
Daniela B Miraglia et al.
Journal of colloid and interface science, 351(1), 197-202 (2010-08-17)
The dependence of the aggregation number (N(agg)) on composition and concentration of sodium oleate-cetyltrimethylammonium bromide mixed micelles as revealed by cyclic voltammetry experiments shows a complex relationship with the total concentration and the composition of surfactant mixtures. This behavior is
Yuan-Ting Zhu et al.
Food chemistry, 173, 521-526 (2014-12-04)
Oolong tea is an important member in tea family, which claims for various health benefits such as preventing obesity and improving lipid metabolism. In this work, using pancreatic lipase (PL) functionalised magnetic nanoparticles (PL-MNPs) as solid phase extraction absorbent in
Sanela M Đorđević et al.
International journal of pharmaceutics, 493(1-2), 40-54 (2015-07-26)
This paper describes design and evaluation of parenteral lecithin-based nanoemulsions intended for brain delivery of risperidone, a poorly water-soluble psychopharmacological drug. The nanoemulsions were prepared through cold/hot high pressure homogenization and characterized regarding droplet size, polydispersity, surface charge, morphology, drug-vehicle
Elaine F Enright et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 153, 68-83 (2020-05-31)
Oral delivery of poorly water-soluble drugs (PWSDs), which predominate the development pipeline, poses significant challenges. Weakly basic compounds, such as atazanavir, represent a critical class of PWSDs as even the administration of the crystalline solid may invoke supersaturation during gastric-intestinal
Fuyao Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(30), 3676-3685 (2015-04-29)
Hydrophobic ultrasmall nanoparticles synthesized in nonpolar solvents exhibit great potential in biomedical applications. However, a major challenge when applying these nanomaterials in biomedical research is the lack of a versatile strategy to render them water dispersible while preserving the hydrodynamic
Matthew B Dowling et al.
Langmuir : the ACS journal of surfaces and colloids, 25(15), 8519-8525 (2009-03-26)
We describe a new way to impart pH-responsive properties to gels of biopolymers such as gelatin. This approach involves the embedding of pH-sensitive nanosized vesicles within the gel. The vesicles employed here are those of sodium oleate (NaOA), a fatty-acid-based
Cheng-Shiuan Li et al.
Nature communications, 6, 6538-6538 (2015-03-11)
Carbon dioxide capture and use as a carbon feedstock presents both environmental and industrial benefits. Here we report the discovery of a hybrid oxide catalyst comprising manganese oxide nanoparticles supported on mesoporous spinel cobalt oxide, which catalyses the conversion of
Virginia Pardo et al.
The Journal of biological chemistry, 290(18), 11663-11677 (2015-03-21)
Chronic low grade inflammation in adipose tissue during obesity is associated with an impairment of the insulin signaling cascade. In this study, we have evaluated the impact of palmitate or oleate overload of macrophage/Kupffer cells in triggering stress-mediated signaling pathways
Olivier Briand et al.
Molecular endocrinology (Baltimore, Md.), 26(3), 399-413 (2012-02-04)
The NR4A orphan nuclear receptors Nur77, Nurr1, and Nor1 exert multiple cellular and metabolic functions. These transcriptional regulators are activated in response to extracellular stresses, including lipotoxic fatty acids (FA) and proinflammatory cytokines. The contribution of NR4As to β-cell pathophysiology
Penny Beckerson et al.
The Biochemical journal, 465(1), 127-137 (2014-10-21)
Cytoglobin (Cygb) is a hexa-co-ordinate haem protein from the globin superfamily with a physiological function that is unclear. We have previously reported that the haem co-ordination is changed in the presence of lipids, potentially transforming the redox properties of the
J Schmitt et al.
British journal of cancer, 111(8), 1646-1656 (2014-08-20)
Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover. Here, we investigated whether tumorigenesis in cancer-derived prostate epithelial cell lines influences protein kinase C-linked turnover of ethanolamine phosphoglycerides (EtnPGs) and alters the pattern of ethanolamine (Etn) metabolites
Shenghong Zhong et al.
Soft matter, 11(35), 6999-7004 (2015-08-05)
Here, we report the development of an experimental system based on liquid crystals (LCs) confined in microcapillaries for imaging interfacial phenomena. The inner surfaces of the microcapillaries were modified with octadecyltrichlorosilane to promote an escaped-radial configuration of LCs. We checked
Yoshikazu Kameshima et al.
International journal of pharmaceutics, 381(1), 34-39 (2009-08-04)
Mg-Al-ascorbic acid (ASA)-layered double hydroxides (ASA-LDHs) with Mg/Al=3 were synthesized by ion-exchange, coprecipitation and reconstruction methods. Composites with sodium oleate (SOA)/ASA-LDH were prepared by an ion-exchange method using various concentrations of SOA solutions. The (003) basal spacing of the ASA-LDHs
Dylan T King et al.
Langmuir : the ACS journal of surfaces and colloids, 27(18), 11381-11393 (2011-08-16)
The prediction of surfactant phase behavior has applications in a wide range of areas. An accurate modeling of liquid phase behavior can aid our understanding of colloidal process or be used to design phases that respond in a defined way
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