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Neha Kaushik et al.
Scientific reports, 5, 8587-8587 (2015-02-27)
In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma
Ivy Wilkinson-Ryan et al.
PloS one, 10(5), e0125851-e0125851 (2015-05-02)
One strategy in cancer immunotherapy is to capitalize on the key immunoregulatory and antigen presenting capabilities of dendritic cells (DCs). This approach is dependent on efficient delivery of tumor specific antigens to DCs, which subsequently induce an anti-tumor T-cell mediated
Senthilkumar K Sakthivel et al.
Journal of immune based therapies and vaccines, 6, 6-6 (2008-10-30)
Alterations in serum CXCR3 ligand levels were examined in interstitial cystitis (IC) patients; similar expression patterns in serum as well as CXCR3, CXCR3 ligands, and cytokines expressed by peripheral and local leukocyte subpopulations were characterized during cyclophosphamide (CYP)-induced acute cystitis
Ezgi Bayram et al.
Artificial cells, nanomedicine, and biotechnology, 42(6), 418-422 (2013-07-25)
In the biosensor construction, 3-mercaptopropionic acid (3-MPA) and 6-aminocaproic acid (6-ACA) were used for forming self-assembled monolayer (SAM) on a gold disc electrode and pyruvate oxidase was immobilized on the modified electrode surface by using glutaraldehyde. Biosensor response is linearly
N Craig Carville et al.
Journal of biomedical materials research. Part A, 103(8), 2540-2548 (2014-12-17)
In this work, the influence of substrate surface charge on in vitro osteoblast cell proliferation on ferroelectric lithium niobate (LN) crystal surfaces is investigated. LN has a spontaneous polarization along the z-axis and is thus characterized by positive and negative
Lukasz Szoka et al.
Molecular and cellular biochemistry, 403(1-2), 51-60 (2015-01-30)
The oxythiamine (OXY) is antivitamin of thiamine. The finding that OXY increases the cytoplasmic concentration of pyruvate, known to enhance collagen biosynthesis, led us to investigate the mechanism of this antivitamin action on collagen biosynthesis in cultured human skin fibroblasts.
Jian He et al.
The American journal of Chinese medicine, 43(2), 305-317 (2015-03-27)
Ginsenoside Rg1 has been reported to possess anti-inflammatory activities, but the effects of Rg1 on the shear induced MCP-1 upregulation mechanism on endothelial cells (ECs) remain to be determined. In this study, we show that Rg1 down modulates shear induced
Zhixu Ni et al.
Analytical and bioanalytical chemistry, 407(17), 5161-5173 (2015-02-24)
Oxidized lipids play a significant role in the pathogenesis of numerous oxidative stress-related human disorders, such as atherosclerosis, obesity, inflammation, and autoimmune diseases. Lipid peroxidation, induced by reactive oxygen and nitrogen species, yields a high variety of modified lipids. Among
Yoo Suk Kim et al.
Annals of biomedical engineering, 43(9), 2153-2162 (2015-02-01)
The role of three-dimensional (3D) printing has expanded in diverse areas in medicine. As plastic surgery needs to fulfill the different demands from diverse individuals, the applications of tailored 3D printing will become indispensable. In this study, we evaluated the
Niraj Kumar et al.
BMC biotechnology, 8, 42-42 (2008-04-24)
To ensure maximal productivity of recombinant proteins (rP) during production culture it is typical to encourage an initial phase of rapid cell proliferation to achieve high biomass followed by a stationary phase where cellular energies are directed towards production of
Kelly Brooks et al.
Pigment cell & melanoma research, 27(5), 813-821 (2014-06-04)
Melanoma cell lines are commonly defective for the G2-phase cell cycle checkpoint that responds to incomplete catenation of the replicated chromosomes. Here, we demonstrate that melanomas defective for this checkpoint response are less sensitive to genotoxic stress, suggesting that the
Kakkad Regha et al.
Nature communications, 6, 7203-7203 (2015-05-29)
Acute myeloid leukaemia (AML) is characterized by a block in myeloid differentiation the stage of which is dependent on the nature of the transforming oncogene and the developmental stage of the oncogenic hit. This is also true for the t(8;21)
Merav Cohen et al.
The EMBO journal, 33(24), 2906-2921 (2014-11-12)
Tissue microenvironment influences the function of resident and infiltrating myeloid-derived cells. In the central nervous system (CNS), resident microglia and freshly recruited infiltrating monocyte-derived macrophages (mo-MΦ) display distinct activities under pathological conditions, yet little is known about the microenvironment-derived molecular
Seyhan Boyoglu-Barnum et al.
Journal of virology, 88(18), 10569-10583 (2014-07-06)
Respiratory syncytial virus (RSV) is the single most important cause of serious lower respiratory tract infections in young children, yet no highly effective treatment or vaccine is available. In the present study, we investigated the effect of prophylactic treatment with
Amanda Trent et al.
The AAPS journal, 17(2), 380-388 (2014-12-21)
Delivery system design and adjuvant development are crucially important areas of research for improving vaccines. Peptide amphiphile micelles are a class of biomaterials that have the unique potential to function as both vaccine delivery vehicles and self-adjuvants. In this study
Agnieszka Krupa et al.
Mediators of inflammation, 2015, 124762-124762 (2015-08-25)
Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial
Yating Cheng et al.
Oncotarget, 6(13), 10840-10852 (2015-04-29)
HOTTIP is a long non-coding RNA (lncRNA) transcribed from the 5' tip of the HOXA locus and is associated with the polycomb repressor complex 2 (PRC2) and WD repeat containing protein 5 (WDR5)/mixed lineage leukemia 1 (MLL1) chromatin modifying complexes.
Sun-Jin Kim et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(20), 4630-4641 (2015-06-25)
The objective of the study was to determine whether astrocytes and brain endothelial cells protect glioma cells from temozolomide through an endothelin-dependent signaling mechanism and to examine the therapeutic efficacy of the dual endothelin receptor antagonist, macitentan, in orthotopic models
Thabe M Matsebatlela et al.
Chemico-biological interactions, 233, 95-105 (2015-04-07)
Didox (3,4-dihydroxy-benzohydroxamic acid), is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid, and originally developed as an anti-cancer agent. Some studies indicate that didox may have anti-oxidative stress-like properties, while other studies hint that didox may have
Hadi Ghaffari et al.
Life sciences, 113(1-2), 7-13 (2014-07-25)
Oxidative stress plays a key role in several ailments including neurodegenerative conditions. The aim of the study was to demonstrate the effect of rosmarinic acid (RA) in preventing oxidative stress related death of neuronal cell lines. In the present study
Qisheng Zuo et al.
PloS one, 10(2), e0109469-e0109469 (2015-02-07)
Here, we explore the regulatory mechanism of lipid metabolic signaling pathways and related genes during differentiation of male germ cells in chickens, with the hope that better understanding of these pathways may improve in vitro induction. Fluorescence-activated cell sorting was
Meng Gao et al.
Journal of cellular physiology, 236(4), 2920-2933 (2020-09-16)
The previous research has shown that mitochondrial flash (mitoflash) genesis are functionally and mechanistically integrated with mitochondrial electron transport chain (ETC) energy metabolism. However, the response of mitoflash to superoxide is not entirely consistent with the response of MitoSOX Red.
Yuanfeng Wu et al.
Biochemical pharmacology, 95(4), 324-336 (2015-04-11)
Tolvaptan, a vasopressin receptor 2 antagonist used to treat hyponatremia, has recently been reported to be associated with an increased risk of liver injury. In this study, we explored the underlying mechanisms of hepatotoxicity of tolvaptan using human HepG2 cells.
Ziad Julier et al.
Scientific reports, 5, 8569-8569 (2015-02-25)
Fibronectin (FN) is an extracellular matrix (ECM) protein including numerous fibronectin type III (FNIII) repeats with different functions. The alternatively spliced FN variant containing the extra domain A (FNIII EDA), located between FNIII 11 and FNIII 12, is expressed in
Elodie Décembre et al.
PLoS pathogens, 10(10), e1004434-e1004434 (2014-10-24)
Dengue virus (DENV) is the leading cause of mosquito-borne viral illness and death in humans. Like many viruses, DENV has evolved potent mechanisms that abolish the antiviral response within infected cells. Nevertheless, several in vivo studies have demonstrated a key
Chengguang Zhao et al.
Oncotarget, 6(16), 14472-14487 (2015-05-12)
K-Ras mutations are frequently detected in pancreatic and colon cancers, which are associated with the resistance to MEK inhibitors targeting the Ras pathway. Identifying the underlying mechanisms for the acquired resistance is essential for the future clinical development of MEK
Michelle L McCully et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 96-104 (2015-05-24)
The localization of memory T cells to human skin is essential for long-term immune surveillance and the maintenance of barrier integrity. The expression of CCR8 during naive T cell activation is controlled by skin-specific factors derived from epidermal keratinocytes and
Alessandra Ferramosca et al.
BioMed research international, 2015, 645984-645984 (2015-08-25)
In recent years, several studies focused their attention on the role of dietary fats in the pathogenesis of hepatic steatosis. It has been demonstrated that a high-fat diet is able to induce hyperglycemia, hyperinsulinemia, obesity, and nonalcoholic fatty liver disease.
A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers.
Kimberly A Toops et al.
Experimental eye research, 124, 74-85 (2014-05-28)
Antonella Sassano et al.
Molecular and cellular biology, 35(15), 2684-2698 (2015-05-28)
We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs
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