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PHR1000

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Saunders Handbook of Veterinary Drugs - E-Book: Small and Large Animal (2010)
Pierre-Yves Collart-Dutilleul et al.
Nanoscale research letters, 9(1), 564-564 (2014-11-12)
The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward. Lamellipodia are the primary area within the cell of actin
Ramu Adela et al.
PloS one, 10(4), e0125270-e0125270 (2015-04-22)
We have previously reported that increased glucose levels were associated with higher serum nitric oxide (NO) levels in fructose-fed insulin resistant rats. However, the relationship between hyperglycemia and serum NO level was not clear. Therefore, the present study was designed
A E-L Au et al.
Cell death & disease, 5, e1410-e1410 (2014-09-12)
Platelet activation is a frontline response to injury, not only essential for clot formation but also important for tissue repair. Indeed, the reparative influence of platelets has long been exploited therapeutically where application of platelet concentrates expedites wound recovery. Despite
Rodrigo Almeida-Paes et al.
PLoS neglected tropical diseases, 8(9), e3094-e3094 (2014-09-19)
There have been several recent changes in the taxonomy of Sporothrix schenckii as well as new observations regarding the clinical aspects of sporotrichosis. In this study, we determined the identification of the Sporothrix species associated with both classic and unusual
Woo-Sung Kwon et al.
BMC genomics, 15, 897-897 (2014-10-16)
Mammalian spermatozoa must undergo capacitation, before becoming competent for fertilization. Despite its importance, the fundamental molecular mechanisms of capacitation are poorly understood. Therefore, in this study, we applied a proteomic approach for identifying capacitation-related proteins in boar spermatozoa in order
Xin Xiao et al.
Scientific reports, 5, 9409-9409 (2015-03-24)
The porous architectural characteristics of biomaterials play an important role in scaffold revascularization. However, no consensus exists regarding optimal interconnection sizes for vascularization and its scaffold bioperformance with different interconnection sizes. Therefore, a series of disk-type beta-tricalcium phosphates with the
Thomas C Glenn et al.
Acta neurochirurgica. Supplement, 118, 115-119 (2013-07-24)
Proton nuclear magnetic resonance (H-NMR) spectroscopic analysis of cerebral spinal fluid provides a quick, non-invasive modality for evaluating the metabolic activity of brain-injured patients. In a prospective study, we compared the CSF of 44 TBI patients and 13 non-injured control
Daniel P Tonge et al.
PloS one, 9(4), e93849-e93849 (2014-04-15)
Next generation sequencing technology has revolutionised microbiology by allowing concurrent analysis of whole microbial communities. Here we developed and verified similar methods for the analysis of fungal communities using a proton release sequencing platform with the ability to sequence reads
Tian-Bo Zhang et al.
Journal of pharmaceutical and biomedical analysis, 102, 1-8 (2014-09-16)
Shuang-Huang-Lian oral liquid (SHL) is a well-known Chinese patent drug containing three herbal medicines: Radix Scutellariae, Flos Lonicerae Japonicae and Fructus Forsythiae. It is usually used to treat acute upper respiratory tract infection caused by virus or bacteria. Although the
Gerald S Supinski et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(8), 921-929 (2014-08-30)
Recent work indicates that infections are a major contributor to diaphragm weakness in patients who are critically ill and mechanically ventilated, and that diaphragm weakness is a risk factor for death and prolonged mechanical ventilation. Infections activate muscle calpain, but
Simone Kersseboom et al.
Molecular endocrinology (Baltimore, Md.), 28(12), 1961-1970 (2014-11-13)
Monocarboxylate transporter 8 (MCT8) transports thyroid hormone (TH) across the plasma membrane. Mutations in MCT8 result in the Allan-Herndon-Dudley syndrome, comprising severe psychomotor retardation and elevated serum T3 levels. Because the neurological symptoms are most likely caused by a lack
Prashant Nadkarni et al.
Progress in molecular biology and translational science, 121, 23-65 (2014-01-01)
Glucagon-like peptide-1(7-36)amide (GLP-1) is a secreted peptide that acts as a key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric emptying, to enhance pancreatic insulin secretion, and to suppress pancreatic glucagon secretion. GLP-1 is secreted
Tadahiro Suzuki et al.
Toxins, 7(1), 187-200 (2015-01-23)
Host plants excrete a glucosylation enzyme onto the plant surface that changes mycotoxins derived from fungal secondary metabolites to glucosylated products. Deoxynivalenol-3-glucoside (DON3G) is synthesized by grain uridine diphosphate-glucosyltransferase, and is found worldwide, although information on its toxicity is lacking.
Phing-How Lou et al.
Anesthesia and analgesia, 120(2), 329-340 (2014-12-02)
The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown. Hearts of healthy and type-2 diabetic rats (generated by fructose
Frederika Maria Byrne et al.
Journal of diabetes research, 2015, 752481-752481 (2015-03-12)
Chronic pain is a common complication of diabetes. The aim of the present study was to characterise pain behaviour in a high fat diet/streptozotocin (HFD/STZ) model of diabetes in the rat, investigate spinal mechanisms, and determine the effects of antidiabetic
Fábio H Silva et al.
The journal of sexual medicine, 11(11), 2661-2670 (2014-09-10)
Cardiovascular and endocrine-metabolic diseases associated with increased oxidative stress such as obesity lead to erectile dysfunction (ED). Activators of soluble guanylyl cyclase (sGC) such as BAY 60-2770 reactivate the heme-oxidized sGC in vascular diseases. This study aimed to evaluate the
Carlo Giuseppe Rizzello et al.
Applied and environmental microbiology, 81(9), 3192-3204 (2015-03-01)
Triticum turgidum subsp. durum was grown according to four farming systems: conventional (CONV), organic with cow manure (OMAN) or green manure (OLEG), and without inputs (NOINPUT). Some chemical and technological characteristics differed between CONV and organic flours. As shown by
H-T Dou et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(4), 753-762 (2014-12-05)
The purpose of this study was to investigate the molecular characteristics of 83 clinical Cryptococcus neoformans/C. gattii species complex isolated in Beijing, China, between 2007 and 2013. Restriction fragment length polymorphism of the gene URA5 (URA5-RFLP), multilocus sequence typing (MLST)
Rachael K Nelson et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 39(7), 811-818 (2014-04-30)
Although regular exercise is associated with reduced cardiometabolic disease risk among overweight adults, it remains unclear whether much of the health benefits of exercise are derived from the most recent session(s) of exercise or if they are the result of
Daifeng Cheng et al.
Scientific reports, 4, 7489-7489 (2014-12-17)
Reproduction is an important life process in insects; however, few studies have attempted to demonstrate the association between reproductive activity and energy metabolism. To address this problem, we focused on the reproductive changes in Bactrocera dorsalis males. We analyzed B.
Monsicha Pongpom et al.
Infection and immunity, 83(3), 923-933 (2014-12-24)
In Aspergillus nidulans, the AcuK and AcuM transcription factors form a complex that regulates gluconeogenesis. In Aspergillus fumigatus, AcuM governs gluconeogenesis and iron acquisition in vitro and virulence in immunosuppressed mice. However, the function of AcuK was previously unknown. Through
Zuhal Guvenalp et al.
Pharmaceutical biology, 53(6), 888-896 (2014-11-29)
Mentha L. (Labiatae) species (mint) with their flavoring properties have been used in food industries for centuries. Besides they have a great importance in drug development and medicinal applications due to various bioactive compounds of several members of the genus.
Janice K Kiecolt-Glaser et al.
Psychoneuroendocrinology, 52, 239-250 (2014-12-17)
Longitudinal studies have implicated both marital distress and depression in the development of the metabolic syndrome, a risk factor for diabetes and cardiovascular disease. This study addressed the impact of hostile marital interactions and a mood disorder history on obesity-related
Ke Wang et al.
Anti-cancer drugs, 26(1), 15-24 (2014-09-18)
Curcumin, the major pigment of the dietary spice turmeric, has the potential for chemoprevention by promotion of apoptosis. Here, we investigated the molecular mechanisms of curcumin in glycolytic inhibition and apoptotic induction in human colorectal cancer HCT116 and HT29 cells.
Shin-Yi Lee Marzano et al.
Journal of virology, 89(9), 5060-5071 (2015-02-20)
A recombinant strain of Sclerotinia sclerotiorum hypovirus 2 (SsHV2) was identified from a North American Sclerotinia sclerotiorum isolate (328) from lettuce (Lactuca sativa L.) by high-throughput sequencing of total RNA. The 5'- and 3'-terminal regions of the genome were determined
Itay Israel Shemesh et al.
PloS one, 9(12), e114287-e114287 (2014-12-05)
Diabetic nephropathy (DN) is characterized by proliferation of mesangial cells, mesangial expansion, hypertrophy and extracellular matrix accumulation. Previous data have cross-linked PKB (AKT) to TGFβ induced matrix modulation. The non-toxic compound AS101 has been previously shown to favorably affect renal
Dong-il Kim et al.
Archives of biochemistry and biophysics, 560, 36-43 (2014-07-30)
Hyperglycemia-induced apoptosis of retinal pigment epithelial (RPE) cells is considered to be involved in the progression of diabetic retinopathy. Histone arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) has emerged as an important histone modification involved in gene regulation. However
Ken-ichi Sato et al.
Natural product communications, 8(7), 987-998 (2013-08-29)
This report describes the stereocontrolled total synthesis of the multi-functionalized cyclitol derivative, tetrodotoxin, containing eight asymmetric carbons and different types of branched-chains, from myo-inositol and D-glucose using three different methods. The tetrodotoxin derivatives possess a relatively small molecular weight but
S A Menzikov et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (1)(1), 33-36 (2013-06-29)
Effect of the glucose and Mg(2+)-ATP on the coupled with CABA(A)-receptor Cl-,HCO3(-)-activated Mg(2+)-ATPase of the plasma membranes from rat brain involving from "basal" Mg(2+)-ATPase which it is activated by Cl-,HCO3(-) ions it was investigated. The glucose (1-10 mM) decreased the
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