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phr1000

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Andreina Ricci et al.
Journal of mass spectrometry : JMS, 50(1), 228-234 (2015-01-21)
Understanding on a molecular level the acid-catalysed decomposition of the sugar monomers from hemicellulose and cellulose (e.g. glucose, xylose), the main constituent of lignocellulosic biomass is very important to increase selectivity and reaction yields in solution, key steps for the development
Riccardo D'Elia et al.
BMC genomics, 10, 492-492 (2009-10-27)
Trichuris muris in the mouse is an invaluable model for infection of man with the gastrointestinal nematode Trichuris trichiura. Three T. muris isolates have been studied, the Edinburgh (E), the Japan (J) and the Sobreda (S) isolates. The S isolate
Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice.
Ingo B Leibiger et al.
Nature medicine, 21(1), 14-16 (2015-01-09)
Nadya Shusharina et al.
International journal of radiation oncology, biology, physics, 89(1), 137-144 (2014-04-15)
To investigate the spatial correlation between high uptake regions of 2-deoxy-2-[(18)F]-fluoro-D-glucose positron emission tomography ((18)F-FDG PET) before and after therapy in recurrent lung cancer. We enrolled 106 patients with inoperable lung cancer into a prospective study whose primary objectives were
Prithy Rupa et al.
Journal of agricultural and food chemistry, 62(39), 9479-9487 (2014-09-13)
Food allergies are attributed to an imbalance in immune response to ubiquitous antigens. A previous study demonstrated that mannose glycation (mannosylation) of ovalbumin decreased allergenicity in vivo. The proposed research targets mannosylation of various common allergens that may help prevent
Jie Zhang et al.
Phytochemistry, 108, 157-170 (2014-12-03)
The MeOH extract of defatted shea (Vitellaria paradoxa; Sapotaceae) kernels was investigated for its constituents, and fifteen oleanane-type triterpene acids and glycosides, two steroid glucosides, two pentane-2,4-diol glucosides, seven phenolic compounds, and three sugars, were isolated. The structures of five
Jason M Tonne et al.
Diabetologia, 58(2), 313-323 (2014-10-24)
Achieving a better understanding of beta cell regeneration after immunological destruction is crucial for the development of immunotherapy approaches for type 1 diabetes. In previous type 1 diabetes models, sustained immune activation eliminates regenerating beta cells, thus limiting the study
Saidan Ding et al.
The international journal of biochemistry & cell biology, 55, 252-263 (2014-09-16)
We previously demonstrated that dopamine (DA) overload may be a key mechanism behind development of minimal hepatic encephalopathy (MHE) in rats. It has been shown that low-grade cerebral oedema and oxidative stress play important roles in the pathogenesis of MHE.
Sarbani Mohan et al.
Molecular immunology, 62(1), 249-264 (2014-07-22)
Streptococcus pneumoniae is a Gram-positive bacterium, causing acute sinusitis, otitis media, and severe diseases such as pneumonia, bacteraemia, meningitis and sepsis. Here we identify elongation factor Tu (Tuf) as a new Factor H binding protein of S. pneumoniae. The surface
Mio Okada et al.
Journal of breath research, 8(4), 046004-046004 (2014-11-02)
Transplantation of insulin (INS)-secreting cells differentiated in vitro from stem cells promises a safer and easier treatment of severe diabetes mellitus. A volatile bioactive compound, hydrogen sulfide (H2S), promotes cell differentiation; human tooth-pulp stem cells undergo hepatic differentiation. The aim
Digar Singh et al.
Biotechnology progress, 30(5), 1196-1205 (2014-07-22)
Swainsonine, a secondary metabolite from Metarhizium anisopliae has been extensively studied in the complementary areas of therapeutics and toxicology. This work aims to develop a simple UV-HPLC method of analyses for swainsonine in Metarhizium fermentation broth and to explore its
Ana G Ramos-Martínez et al.
Experimental lung research, 41(1), 1-11 (2014-10-03)
Explore the temporal expression of metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) during experimental tuberculosis induced by virulent Mycobacterium tuberculosis strain H37Rv. BALB/c mice were infected via endotracheal instillation with H37Rv. Groups of mice were euthanized at different time
Andy Maloney et al.
PeerJ, 2, e284-e284 (2014-04-09)
We show for the first time the effects of heavy-hydrogen water ((2)H2O) and heavy-oxygen water (H2 (18)O) on the gliding speed of microtubules on kinesin-1 coated surfaces. Increased fractions of isotopic waters used in the motility solution decreased the gliding
J Gui et al.
Placenta, 36(4), 410-418 (2015-02-17)
Gestational diabetes (GDM) is associated with long-term cardiovascular and metabolic diseases in offspring. However, the mechanisms are not well understood. We explored whether fetal exposure to a diabetic environment is associated with fetal endothelial progenitor cell dysfunction, and whether vitamin
M J Farrell et al.
Osteoarthritis and cartilage, 23(1), 134-142 (2014-09-23)
Tissue engineering approaches for cartilage repair have focused on the use of mesenchymal stem cells (MSCs). For clinical success, MSCs must survive and produce extracellular matrix in the physiological context of the synovial joint, where low nutrient conditions engendered by
Ke Wang et al.
PloS one, 9(5), e96894-e96894 (2014-05-14)
Diabetes exacerbates abnormal vascular smooth muscle cell (VSMC) accumulation in response to arterial wall injury. Vinpocetine has been shown to improve vascular remolding; however, little is known about the direct effects of vinpocetine on vascular complications mediated by diabetes. The
N V Batista et al.
Clinical and experimental immunology, 178(3), 416-427 (2014-08-13)
The prevalence of food allergy is rising in the western world. Allergen restriction is the chosen treatment in this condition, but continuous ingestion of the antigen has shown positive results in clinical trials. In a previous study, we have shown
Handbook of Starch Hydrolysis Products and their Derivatives (1995)
Yi-Chun Chen et al.
Diabetologia, 57(10), 2066-2075 (2014-07-06)
EGF and gastrin co-administration reverses type 1 diabetes in rodent models. However, the failure of this to translate into a clinical treatment suggests that EGF-mediated tissue repair is a complicated process and warrants further investigation. Thus, we aimed to determine
Zhongqi Fan et al.
BioMed research international, 2015, 960357-960357 (2015-03-31)
The microbial cell wall plays a crucial role in biofilm formation and drug resistance. cspA encodes a repeat-rich glycophosphatidylinositol-anchored cell wall protein in the pathogenic fungus Aspergillus fumigatus. To determine whether cspA has a significant impact on biofilm development and
Roosmarijn Tm van Hooijdonk et al.
Annals of intensive care, 4(1), 8-8 (2014-03-07)
OptiScanner devices, continuous glucose monitoring devices that perform automated blood draws via a central venous catheter and create plasma through centrifugation, measure plasma glucose levels through mid-infrared spectroscopy at the bedside. The objective of this study was to determine accuracy
Michal Rivlin et al.
Magnetic resonance in medicine, 72(5), 1375-1380 (2014-09-23)
To evaluate the feasibility to detect tumors and metastases by the chemical exchange saturation transfer (CEST) MRI technique using 3-O-Methyl-D-glucose (3OMG), a nonmetabolizable derivative of glucose that is taken up rapidly and preferentially by tumors and is entirely excreted by
Anne E Purfield et al.
Malaria journal, 8, 104-104 (2009-05-16)
DB289, [2,5-bis(4-amidinophenyl)furan bis-O-methylamidoxime], is a broad spectrum anti-parasitic compound which has been shown to be effective against malaria in recent clinical trials. DB75, [2,5-bis(4-amidinophenyl)furan], is the active metabolite of this drug. The objective of this study was to determine the
Jiayin Wu et al.
Molecular immunology, 64(2), 235-243 (2015-01-01)
Innate immunity is considered to be critical in the pathogenesis of fungal keratitis. Pattern recognition receptors (PRRs) recognize conserved microbial structures called pathogen-associated molecular patterns (PAMPS), thereby initiating the innate immunity. Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors
Ilaria De Pasquale et al.
Applied and environmental microbiology, 80(19), 6243-6255 (2014-08-03)
Pyrosequencing of the 16S rRNA targeting RNA, community-level physiological profiles made with Biolog EcoPlates, proteolysis, and volatile component (VOC) analyses were mainly used to characterize the manufacture and ripening of the pasta filata cheese Caciocavallo Pugliese. Plate counts revealed that
Edwin L de Vrij et al.
PloS one, 9(4), e93218-e93218 (2014-04-12)
Hibernation is an energy-conserving behavior in winter characterized by two phases: torpor and arousal. During torpor, markedly reduced metabolic activity results in inactivity and decreased body temperature. Arousal periods intersperse the torpor bouts and feature increased metabolism and euthermic body
Mark-Steven Steiner et al.
Chemical Society reviews, 40(9), 4805-4839 (2011-06-16)
This critical review covers the present state of the art in optical sensing of glucose. Following an introduction into the significance of (continuous) sensing of glucose and a brief look back, we discuss methods based on (a) monitoring the optical
Desiree DeMille et al.
IUBMB life, 65(11), 921-929 (2013-11-23)
Per-Arnt-Sim (PAS) kinase (PASK, PASKIN, and PSK) is a member of the group of nutrient sensing protein kinases. These protein kinases sense the energy or nutrient status of the cell and regulate cellular metabolism appropriately. PAS kinase responds to glucose
Li Li et al.
International journal of pharmaceutics, 471(1-2), 339-348 (2014-06-19)
Poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL) micelles dually loaded with both pheophorbide a (PhA) as a photosensitizer and β-carotene (CAR) as a singlet oxygen ((1)O2) scavenger were designed to control photodynamic therapy (PDT) activity in cancer treatment. The CAR in the PhA/CAR micelles
Nisha D Sherma et al.
Proteome science, 12(1), 52-52 (2014-10-21)
The cytokine MIF (Macrophage Migration Inhibitory Factor) has diverse physiological roles and is present at elevated concentrations in numerous disease states. However, its molecular heterogeneity has not been previously investigated in biological samples. Mass Spectrometric Immunoassay (MSIA) may help elucidate
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