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[Cytotoxicity of PVC tubes sterilized in ethylene oxide after gamma radiation exposure].

Revista da Escola de Enfermagem da U S P (2013-06-08)
Rafael Queiroz de Souza, Kazuko Uchikawa Graziano, Tamiko Ichikawa Ikeda, Cláudia Regina Gonçalves, Aurea Silveira Cruz
ABSTRACT

Do materials sterilized using gamma rays become toxic when re-sterilized in ethylene oxide? This question guided the objective of this study, which was to investigate the potential cytotoxic effect of PVC sterilized by gamma radiation and re-sterilized with EO by the agar diffusion method in cell cultures. Nine PVC tubes were subjected to gamma radiation sterilization and were re-sterilized in EO. The tubes were divided into a total of 81 units of analysis that were tested so as to represent the internal and external surfaces and mass of each tube. It was concluded that the PVC materials sterilized in gamma radiation and re-sterilized in EO are not cytotoxic.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Poly(vinyl chloride), low molecular weight
Sigma-Aldrich
Poly(vinyl chloride), high molecular weight
Sigma-Aldrich
Poly(vinyl chloride), average Mw ~80,000, average Mn ~47,000
Supelco
Poly(vinyl chloride), Selectophore, high molecular weight
Supelco
Poly(vinyl chloride), analytical standard, average Mw 85,000 (Typical), average Mn 40,000 (Typical)
Sigma-Aldrich
Poly(vinyl chloride), average Mw ~233,000, average Mn ~99,000
Sigma-Aldrich
Poly(vinyl chloride), average Mw ~62,000, average Mn ~35,000
Poly(vinyl chloride), European Pharmacopoeia (EP) Reference Standard
Supelco
Ethylene oxide solution, certified reference material, 50 mg/mL in methanol
Sigma-Aldrich
Ethylene oxide solution, 2.5-3.3 M in THF