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Lysosomal tartrate sensitive acid phosphatase deficiency in cells which contain lysosomal "high uptake forms".

Biochemical and biophysical research communications (1990-03-16)
P Hu, G Parenti, J Keulemans, A T Hoogeveen
ABSTRACT

The catalytic and immunological properties of acid phosphatases (EC 3.1.3.2.) in different tissues were studied. It was demonstrated that high uptake forms of lysosomal enzymes like beta-galactosidase isolated from human platelets and bovine testis are mature enzymes, which have not lost their mannose-6phosphate marker. The results presented indicate that this phenomenon is related to a low activity or the complete absence of the lysosomal tartrate sensitive acid phosphatase activity in the tissues concerned.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
D-(+)-Mannose, powder, BioReagent, suitable for cell culture
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